Journal article
Chloride channels in the apical membrane of normal and cystic fibrosis airway and intestinal epithelia
American journal of physiology. Lung cellular and molecular physiology, Vol.263(1), pp.L1-L14
07/01/1992
DOI: 10.1152/ajplung.1992.263.1.L1
PMID: 1322048
Abstract
Cl- channels located in the apical membrane of secretory epithelia play a key role in epithelial fluid and electrolyte transport. Dysfunction of one of these channels, cystic fibrosis transmembrane conductance regulator (CFTR), causes the genetic disease cystic fibrosis (CF). We review here the properties and regulation of the different types of Cl- channels that have been reported in airway and intestinal epithelia. We begin by describing the properties of the CFTR Cl- channel and then use those properties as a point of reference. We focused particularly on the evidence that localizes specific types of Cl- channel to the apical membrane. With that background, we assess the biological function of various Cl- channels in airway and intestinal epithelia.
Details
- Title: Subtitle
- Chloride channels in the apical membrane of normal and cystic fibrosis airway and intestinal epithelia
- Creators
- Matthew P Anderson - University of IowaDavid N Sheppard - University of IowaHerbert A Berger - University of IowaMichael J Welsh - University of Iowa
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Lung cellular and molecular physiology, Vol.263(1), pp.L1-L14
- DOI
- 10.1152/ajplung.1992.263.1.L1
- PMID
- 1322048
- NLM abbreviation
- Am J Physiol Lung Cell Mol Physiol
- ISSN
- 1040-0605
- eISSN
- 1522-1504
- Language
- English
- Date published
- 07/01/1992
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Fraternal Order of Eagles Diabetes Research Center; Neurosurgery; Internal Medicine
- Record Identifier
- 9984259444102771
Metrics
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