Journal article
Chlorinated drinking water and bladder cancer: effect of misclassification on risk estimates
Archives of environmental health, Vol.44(4), pp.252-259
07/1989
DOI: 10.1080/00039896.1989.9935891
PMID: 2782947
Abstract
Data are presented from the Iowa portion of the National Bladder Cancer Case-Control Study demonstrating the effect of misclassification on depressing odds ratio estimates for years of exposure to chlorinated drinking water and bladder cancer. Four methods (METHODS 1 through 4) of quantifying chlorination exposure with sequentially decreasing degrees of misclassification are presented for the 268 bladder cancer cases and 658 population-based controls fulfilling criteria for inclusion in this study. Twenty-eight other risk factors for bladder cancer were considered along with chlorinated drinking water exposure estimated by METHOD 4. Stepwise regression models included as significant factors cigarette smoking (p less than .001), chlorination exposure (p = .038), and irradiation to the pelvic area (p = .040). Replacement of chlorinated drinking water exposure estimated by METHOD 4 with any of the remaining three methods resulted in models that included cigarette smoking and irradiation to the pelvic area, but not chlorination exposure. Thus, misclassification of chlorination exposure signified the difference between observing and not observing an association with bladder cancer.
Details
- Title: Subtitle
- Chlorinated drinking water and bladder cancer: effect of misclassification on risk estimates
- Creators
- Charles F Lynch - Department of Preventive Medicine and Environmental Health, University of Iowa, Iowa CityRobert F WoolsonThomas O'GormanKenneth P Cantor
- Resource Type
- Journal article
- Publication Details
- Archives of environmental health, Vol.44(4), pp.252-259
- DOI
- 10.1080/00039896.1989.9935891
- PMID
- 2782947
- NLM abbreviation
- Arch Environ Health
- ISSN
- 0003-9896
- eISSN
- 2331-4303
- Publisher
- United States
- Grant note
- CA39065 / NCI NIH HHS N01CP43200 / NCI NIH HHS 1 K07 CA1181-01A1 / NCI NIH HHS
- Language
- English
- Date published
- 07/1989
- Academic Unit
- Statistics and Actuarial Science; Epidemiology; Biostatistics
- Record Identifier
- 9983996094202771
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