Journal article
Chlorpyrifos exposures in Egyptian cotton field workers
Neurotoxicology (Park Forest South), Vol.31(3), pp.297-304
2010
DOI: 10.1016/j.neuro.2010.02.005
PMCID: PMC3580798
PMID: 20193710
Abstract
Neurobehavioral deficits have been reported in Egyptian pesticide application teams using organophosphorus (OP) pesticides, but whether these effects are related to OP pesticide exposures has yet to be established. In preparation for a comprehensive study of the relationship between OP pesticide dose and neurobehavioral deficits, we assessed exposure within this population. We conducted occupational surveys and workplace observations, and collected air, dermal patch and biological samples from applicators, technicians and engineers involved in chlorpyrifos applications during cotton production to test the hypotheses that: (1) dermal exposure was an important contributor to internal dose and varied across body regions; and (2) substantial differences would be seen across the three job categories. Applicators were substantially younger and had shorter exposure histories than did technicians and engineers. Applicators and technicians were observed to have relatively high levels of skin or clothing contact with pesticide-treated foliage as they walked through the fields. Both dermal patch loadings of chlorpyrifos and measurements of a chlorpyrifos-specific metabolite (TCPy) in urine confirmed substantial exposure to and skin absorption of chlorpyrifos that varied according to job category; and dermal patch loading was significantly higher on the thighs than on the forearms. These findings support our hypotheses and support the need for research to examine neurobehavioral performance and exposures in this population. More importantly, the exposures reported here are sufficiently high to recommend urgent changes in work practices amongst these workers.
Details
- Title: Subtitle
- Chlorpyrifos exposures in Egyptian cotton field workers
- Creators
- Fayssal M Farahat - Department of Community Medicine and Public Health, Faculty of Medicine, Menoufia University, Shebin El-Kom, EgyptRichard A Fenske - Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USAJames R Olson - Department of Pharmacology and Toxicology, State University of New York at Buffalo, Buffalo, NY 14214, USAKit Galvin - Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USAMatthew R Bonner - Department of Pharmacology and Toxicology, State University of New York at Buffalo, Buffalo, NY 14214, USADiane S Rohlman - Center for Research on Occupational and Environmental Toxicology (CROET), Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USATaghreed M Farahat - Department of Community Medicine and Public Health, Faculty of Medicine, Menoufia University, Shebin El-Kom, EgyptPamela J Lein - Center for Research on Occupational and Environmental Toxicology (CROET), Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USAW. Kent Anger - Center for Research on Occupational and Environmental Toxicology (CROET), Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
- Resource Type
- Journal article
- Publication Details
- Neurotoxicology (Park Forest South), Vol.31(3), pp.297-304
- DOI
- 10.1016/j.neuro.2010.02.005
- PMID
- 20193710
- PMCID
- PMC3580798
- NLM abbreviation
- Neurotoxicology
- ISSN
- 0161-813X
- eISSN
- 1872-9711
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 2010
- Academic Unit
- Occupational and Environmental Health; International Programs; Injury Prevention Research Center
- Record Identifier
- 9983997335002771
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