Cholecystectomy and the risk of recurrent colorectal adenomas

Lisa C VINIKOOR; Douglas J ROBERTSON; John A BARON; William B SILVERMAN; Robert S SANDLER

doi:10.1158/1055-9965.EPI-07-0243

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Cholecystectomy and the risk of recurrent colorectal adenomas

Journal article

Open access

Peer reviewed

Cholecystectomy and the risk of recurrent colorectal adenomas

Lisa C VINIKOOR, Douglas J ROBERTSON, John A BARON, William B SILVERMAN and Robert S SANDLER

Cancer epidemiology, biomarkers & prevention, Vol.16(7), pp.1523-1525

2007

DOI: 10.1158/1055-9965.EPI-07-0243

PMID: 17627020

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Abstract

Prior studies have shown an increased risk of colorectal cancer following cholecystectomy, but few studies have explored the association between cholecystectomy and the risk of colorectal adenomas. We used data from three large randomized adenoma chemoprevention trials to explore the association between cholecystectomy and the occurrence of adenomas. After adjusting for confounding factors, we found no increased risk for adenomas among individuals who had undergone cholecystectomy [risk ratio (RR), 1.02; 95% confidence interval (95% CI), 0.88-1.18]. There was a slight increase in the risk of advanced recurrent adenomas (RR, 1.28; 95% CI, 0.94-1.76) and multiple advanced recurrent adenomas (RR, 1.34; 95% CI, 0.97-1.85) but the 95% CIs included the null in both cases. We conclude that the increased risk for colorectal cancer following cholecystectomy seems to be due to a biological process occurring after the adenoma has developed.

Tumors

Gastroenterology. Liver. Pancreas. Abdomen

Stomach. Duodenum. Small intestine. Colon. Rectum. Anus

Biological and medical sciences

Medical sciences

Details

Title: Subtitle: Cholecystectomy and the risk of recurrent colorectal adenomas
Creators: Lisa C VINIKOOR - Department of Epidemiology, School of Public Health, and Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States
Douglas J ROBERTSON - Section of Gastroenterology, VA Medical Center, White River Junction, Vermont, United States
John A BARON - Departments of Medicine and Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire, United States
William B SILVERMAN - Division of Gastroenterology-Hepatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States
Robert S SANDLER - Department of Medicine and Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States
Resource Type: Journal article
Publication Details: Cancer epidemiology, biomarkers & prevention, Vol.16(7), pp.1523-1525
DOI: 10.1158/1055-9965.EPI-07-0243
PMID: 17627020
NLM abbreviation: Cancer Epidemiol Biomarkers Prev
ISSN: 1055-9965
eISSN: 1538-7755
Publisher: American Association for Cancer Research
Language: English
Date published: 2007
Academic Unit: Gastroenterology and Hepatology; Internal Medicine
Record Identifier: 9984094377102771

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