Journal article
Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.275(5), pp.R1431-R1437
11/01/1998
DOI: 10.1152/ajpregu.1998.275.5.R1431
PMID: 9791058
Abstract
The present study investigated the effects of bilateral injections of the nonselective CCK receptor antagonist proglumide or CCK-8 into the lateral parabrachial nuclei (LPBN) on the ingestion of 0.3 M NaCl and water induced by intracerebroventricular injection of ANG II or by a combined treatment with subcutaneous furosemide (Furo) + captopril (Cap). Compared with the injection of saline (vehicle), bilateral LPBN injections of proglumide (50 μg ⋅ 200 nl−1 ⋅ site−1) increased the intake of 0.3 M NaCl induced by intracerebroventricular ANG II (50 ng/1 μl). Bilateral injections of proglumide into the LPBN also increased ANG II-induced water intake when NaCl was simultaneously available, but not when only water was present. Similarly, the ingestion of 0.3 M NaCl and water induced by the treatment with Furo (10 mg/kg) + Cap (5 mg/kg) was increased by bilateral LPBN proglumide pretreatment. Bilateral CCK-8 (0.5 μg ⋅ 200 nl−1 ⋅ site−1) injections into the LPBN did not change Furo + Cap-induced 0.3 M NaCl intake but reduced water consumption. When only water was available after intracerebroventricular ANG II, bilateral LPBN injections of proglumide or CCK-8 had no effect or significantly reduced water intake compared with LPBN vehicle-treated rats. Taken together, these results suggest that CCK actions in the LPBN play a modulatory role on the control of NaCl and water intake induced by experimental treatments that induce hypovolemia and/or hypotension or that mimic those states.
Details
- Title: Subtitle
- Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite
- Creators
- Jose Vanderlei Menani - Departamento de Ciências Fisiológicas, Faculdade de Odontologia, Paulista State University, Araraquara, São Paulo 14801-903, BrazilAlan Kim Johnson - Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242-1407; and
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.275(5), pp.R1431-R1437
- DOI
- 10.1152/ajpregu.1998.275.5.R1431
- PMID
- 9791058
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- Language
- English
- Date published
- 11/01/1998
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213408702771
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