Journal article
Cholesterol Granulomas of the Lungs Associated With Microangiopathic Hemolytic Anemia and Thrombocytopenia in Pulmonary Hypertension: A Case Report and Review of the Literature
Archives of pathology & laboratory medicine (1976), Vol.124(12), pp.1813-1815
12/01/2000
DOI: 10.1043/0003-9985(2000)124<1813:CGOTLA>2.0.CO;2
PMID: 11100063
Abstract
* Cholesterol granulomas unrelated to endogenous lipoid pneumonia, pulmonary alveolar proteinosis, or cholesterol pneumonia are a rare finding during pneumectomy or autopsy. They have been occasionally reported in association with pulmonary hypertension. We report a case where these lesions were associated with long-standing pulmonary hypertension and microangiopathic hemolytic anemia and thrombocytopenia. Plexiform lesions were present in the pulmonary vasculature secondary to pulmonary hypertension, causing hemolysis and thrombocytopenia. We suggest that destruction of red blood cells and platelets could provide membrane lipids that are taken up by phagocytic cells, which promotes the formation of these cholesterol deposits. (Arch Pathol Lab Med. 2000;124:1813-1815)
Details
- Title: Subtitle
- Cholesterol Granulomas of the Lungs Associated With Microangiopathic Hemolytic Anemia and Thrombocytopenia in Pulmonary Hypertension: A Case Report and Review of the Literature
- Creators
- Marcus B NashelskyJohn M MarekAmy MorrisEdgar G Fischer
- Resource Type
- Journal article
- Publication Details
- Archives of pathology & laboratory medicine (1976), Vol.124(12), pp.1813-1815
- Publisher
- College of American Pathologists
- DOI
- 10.1043/0003-9985(2000)124<1813:CGOTLA>2.0.CO;2
- PMID
- 11100063
- ISSN
- 1543-2165
- eISSN
- 1543-2165
- Language
- English
- Date published
- 12/01/2000
- Description audience
- Professional; Academic
- Academic Unit
- Epidemiology; Pathology
- Record Identifier
- 9984047898102771
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