Journal article
Cholesterol Intake Modulates Plasma Triglyceride Levels in Glycosylphosphatidylinositol HDL-Binding Protein 1-Deficient Mice
Arteriosclerosis, thrombosis, and vascular biology, Vol.30(11), pp.2106-2113
2010
DOI: 10.1161/ATVBAHA.110.214403
PMID: 20814015
Abstract
Objective—To determine whether plasma triglyceride levels in adult Glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1)-deficient (Gpihbp1−/−) mice would be sensitive to cholesterol intake. Methods and Results—Gpihbp1−/− mice were fed a Western diet containing 0.15% cholesterol. After 4 to 8 weeks, their plasma triglyceride levels were 113 to 135 mmol/L. When 0.005% ezetimibe was added to the diet to block cholesterol absorption, Lpl expression in the liver was reduced significantly, and the plasma triglyceride levels were significantly higher (>170 mmol/L). We also assessed plasma triglyceride levels in Gpihbp1−/− mice fed Western diets containing either high (1.3%) or low (0.05%) amounts of cholesterol. The high-cholesterol diet significantly increased Lpl expression in the liver and lowered plasma triglyceride levels. Conclusion—Treatment of Gpihbp1−/− mice with ezetimibe lowers Lpl expression in the liver and increases plasma triglyceride levels. A high-cholesterol diet had the opposite effects. Thus, cholesterol intake modulates plasma triglyceride levels in Gpihbp1−/− mice.
Details
- Title: Subtitle
- Cholesterol Intake Modulates Plasma Triglyceride Levels in Glycosylphosphatidylinositol HDL-Binding Protein 1-Deficient Mice
- Creators
- Michael M WEINSTEIN - Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, United StatesYiping Tu - Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, United StatesLoren G FONG - Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, United StatesStephen G YOUNG - Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, United StatesAnne P BEIGNEUX - Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, United StatesBrandon S. J DAVIES - Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, United StatesPeter GIN - Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, United StatesConstance VOSS - Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, United StatesRosemary L WALZEM - Department of Poultry Science and Nutrition and Food Science, Texas A&M University, College Station, Tex, United StatesKaren REUE - Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, United StatesPeter TONTONOZ - Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, United StatesAndré BENSADOUN - Division of Nutritional Science, Cornell University, Ithaca, NY, United States
- Resource Type
- Journal article
- Publication Details
- Arteriosclerosis, thrombosis, and vascular biology, Vol.30(11), pp.2106-2113
- DOI
- 10.1161/ATVBAHA.110.214403
- PMID
- 20814015
- NLM abbreviation
- Arterioscler Thromb Vasc Biol
- ISSN
- 1079-5642
- eISSN
- 1524-4636
- Publisher
- Lippincott Williams & Wilkins; Philadelphia, PA
- Language
- English
- Date published
- 2010
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology
- Record Identifier
- 9984025289302771
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