Journal article
Cholesterol granulomas of the lungs associated with microangiopathic hemolytic anemia and thrombocytopenia in pulmonary hypertension : A case report and review of the literature
Archives of pathology (1960), Vol.124(12), pp.1813-1815
2000
DOI: 10.5858/2000-124-1813-CGOTLA
Abstract
Cholesterol granulomas unrelated to endogenous lipoid pneumonia, pulmonary alveolar proteinosis, or cholesterol pneumonia are a rare finding during pneumectomy or autopsy. They have been occasionally reported in association with pulmonary hypertension. We report a case where these lesions were associated with long-standing pulmonary hypertension and microangiopathic hemolytic anemia and thrombocytopenia. Plexiform lesions were present in the pulmonary vasculature secondary to pulmonary hypertension, causing hemolysis and thrombocytopenia. We suggest that destruction of red blood cells and platelets could provide membrane lipids that are taken up by phagocytic cells, which promotes the formation of these cholesterol deposits.
Details
- Title: Subtitle
- Cholesterol granulomas of the lungs associated with microangiopathic hemolytic anemia and thrombocytopenia in pulmonary hypertension : A case report and review of the literature
- Creators
- Edgar G Fischer - University of New MexicoJohn M Marek - Department of Surgery, University of New Mexico School of Medicine, Albuquerque, NM, United StatesAmy Morris - Department of Surgery, University of New Mexico School of Medicine, Albuquerque, NM, United StatesMarcus B Nashelsky - University of New Mexico
- Resource Type
- Journal article
- Publication Details
- Archives of pathology (1960), Vol.124(12), pp.1813-1815
- Publisher
- College of American Pathologists
- DOI
- 10.5858/2000-124-1813-CGOTLA
- ISSN
- 0363-0153
- Language
- English
- Date published
- 2000
- Academic Unit
- Pathology; Epidemiology
- Record Identifier
- 9984201521602771
Metrics
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