Journal article
Cholesterol, lipoproteins and subclinical interstitial lung disease: the MESA study
Thorax, Vol.72(5), pp.472-474
05/2017
DOI: 10.1136/thoraxjnl-2016-209568
PMCID: PMC5388565
PMID: 28130491
Abstract
We investigated associations of plasma lipoproteins with subclinical interstitial lung disease (ILD) by measuring high attenuation areas (HAA: lung voxels between −600 and −250 Hounsfield units) in 6700 adults and serum MMP-7 and SP-A in 1216 adults age 45–84 without clinical cardiovascular disease in Multi-Ethnic Study of Atherosclerosis. In cross-sectional analyses, each SD decrement in high density lipoprotein cholesterol (HDL-C) was associated with a 2.12% HAA increment (95% CI 1.44% to 2.79%), a 3.53% MMP-7 increment (95% CI 0.93% to 6.07%) and a 6.37% SP-A increment (95% CI 1.35% to 11.13%), independent of demographics, smoking and inflammatory biomarkers. These findings support a novel hypothesis that HDL-C might influence subclinical lung injury and extracellular matrix remodelling.
Details
- Title: Subtitle
- Cholesterol, lipoproteins and subclinical interstitial lung disease: the MESA study
- Creators
- Anna J Podolanczuk - Department of Medicine, Columbia University Medical Center, New York, New York, USAGanesh Raghu - Department of Medicine, University of Washington, Seattle, Washington, USAMichael Y Tsai - Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USASteven M Kawut - Department of Medicine, The Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USAEric Peterson - Department of Medicine, Columbia University Medical Center, New York, New York, USARajiv Sonti - Department of Medicine, Columbia University Medical Center, New York, New York, USADaniel Rabinowitz - Department of Statistics, Columbia University, New York, New York, USACraig Johnson - Department of Biostatistics, University of Washington, Seattle, Washington, USAR Graham Barr - Department of Epidemiology, Columbia University Medical Center, New York, New York, USAKaren Hinckley Stukovsky - Department of Biostatistics, University of Washington, Seattle, Washington, USAEric A Hoffman - Departments of Radiology, Medicine, and Biomedical Engineering, University of Iowa Carver College of Medicine, Iowa City, Iowa, USAJ Jeffrey Carr - Department of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee, USAFiras S Ahmed - Department of Radiology, Columbia University Medical Center, New York, New York, USADavid R Jacobs - Division of Epidemiology & Community Health, University of Minnesota School of Public Health, Minneapolis Minnesota, USAKarol Watson - Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USASteven J Shea - Department of Epidemiology, Columbia University Medical Center, New York, New York, USADavid J Lederer - Department of Epidemiology, Columbia University Medical Center, New York, New York, USA
- Resource Type
- Journal article
- Publication Details
- Thorax, Vol.72(5), pp.472-474
- DOI
- 10.1136/thoraxjnl-2016-209568
- PMID
- 28130491
- PMCID
- PMC5388565
- ISSN
- 0040-6376
- eISSN
- 1468-3296
- Grant note
- DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: HHSN268201500003I, K24-HL-131937, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, R01-93081, R01-HL-077612, R01-HL103676, RC1-100543, T32-H-105323; DOI: 10.13039/100003284, name: Pulmonary Fibrosis Foundation; DOI: 10.13039/100000097, name: National Center for Research Resources, award: UL1-TR-000040, UL1-TR-001079
- Language
- English
- Date published
- 05/2017
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051728902771
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