Journal article
Cholinesterase-inhibiting insecticide toxicity
American family physician, Vol.47(7), pp.1613-1620
05/15/1993
PMID: 8503347
Abstract
Organophosphate toxicity can be fatal. It accounts for almost 40 percent of all insecticide- and pesticide-related illnesses reported by the American Association of Poison Control Centers. Skin contamination is the most important route of occupational exposure. Carbamate insecticides exhibit a similar mechanism of acute toxicity. Organophosphate pesticides act as irreversible acetylcholinesterase inhibitors, while carbamate pesticides produce reversible effects. The inhibition of acetylcholinesterase causes accumulation of acetylcholine at nerve endings, resulting in a cholinergic or hypersecretory syndrome. Persons who are exposed to organophosphates must be admitted to the hospital for careful observation. Symptoms should be treated with atropine, and most patients should also receive pralidoxime, a cholinesterase-regenerating drug.
Details
- Title: Subtitle
- Cholinesterase-inhibiting insecticide toxicity
- Creators
- L J FuortesA D AyeboB C Kross
- Resource Type
- Journal article
- Publication Details
- American family physician, Vol.47(7), pp.1613-1620
- PMID
- 8503347
- ISSN
- 0002-838X
- eISSN
- 1532-0650
- Language
- English
- Date published
- 05/15/1993
- Academic Unit
- Occupational and Environmental Health; Internal Medicine
- Record Identifier
- 9984363587002771
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