Journal article
Chondrocyte senescence and telomere regulation: implications in cartilage aging and cancer (a brief review)
The Iowa orthopaedic journal, Vol.22, pp.1-7
2002
PMCID: PMC1888369
PMID: 12180600
Appears in Diamond Open Access
Abstract
Recent studies on osteoarthritis and the cartilage aging in our laboratory demonstrate that chronologic age correlates with molecular changes in human chondrocytes that affect cell cycle control and replicative life span. These findings indicate that age-related changes in chondrocytes may explain the heightened risk for development of primary osteoarthritis (OA) with increasing age. Concomitant studies of human chondrosarcoma suggest that these aging mechanisms may also play a role in preventing the malignant transformation of chondrocytes. The convergence at the molecular level of these seemingly dissimilar biologic processes provides an excellent opportunity to deepen our understanding of the fundamental processes underlying cartilage neoplasia, cartilage aging, and osteoarthritis.
Details
- Title: Subtitle
- Chondrocyte senescence and telomere regulation: implications in cartilage aging and cancer (a brief review)
- Creators
- Anthony V Mollano - Department of Orthopaedics, University of Iowa Hospitals and Clinics Iowa City 52242, USAJames A MartinJoseph A Buckwalter
- Resource Type
- Journal article
- Publication Details
- The Iowa orthopaedic journal, Vol.22, pp.1-7
- PMID
- 12180600
- PMCID
- PMC1888369
- NLM abbreviation
- Iowa Orthop J
- ISSN
- 1541-5457
- eISSN
- 1555-1377
- Publisher
- Dept. of Orthopaedics, The University of Iowa; United States
- Language
- English
- Date published
- 2002
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Stead Family Department of Pediatrics; Pharmaceutical Sciences and Experimental Therapeutics; Orthopedics and Rehabilitation; Injury Prevention Research Center
- Record Identifier
- 9984040487302771
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