Journal article
Chorioamnionitis-exposure alters serum cytokine trends in premature neonates
Journal of perinatology, Vol.43(6), pp.758-765
06/2023
DOI: 10.1038/s41372-022-01584-2
PMCID: PMC10258137
PMID: 36539561
Abstract
Determine if chronologic age and/or chorioamnionitis exposure alter normal serum cytokine and chemokine levels in uninfected preterm neonates during their initial NICU stay.
A 7-plex immunoassay measured levels of serum IL-1β, IL-6, IL-8, IL-10, TNF-α, CCL2, and CCL3 longitudinally from chorioamnionitis-exposed and unexposed preterm neonates under 33 weeks' gestation.
Chorioamnionitis-exposed and unexposed preterm neonates demonstrated differences in the trends of IL-1β, IL-6, IL-8, IL-10, TNF-α, and CCL2 over the first month of life. The unexposed neonates demonstrated elevated levels of these inflammatory markers in the first two weeks of life with a decrease by the third week of life, while the chorioamnionitis-exposed neonates demonstrated differences over time without a predictable pattern. Chorioamnionitis-exposed and unexposed neonates demonstrated altered IL-10 and TNF-α trajectories over the first twelve weeks of life.
Chorioamnionitis induces a state of immune dysregulation in preterm neonates that persists beyond the immediate neonatal period.
Details
- Title: Subtitle
- Chorioamnionitis-exposure alters serum cytokine trends in premature neonates
- Creators
- Gretchen E Stepanovich - University of MichiganCole A Chapman - University of MichiganKrista L Meserve - University of MichiganJulie M Sturza - University of MichiganLindsay A Ellsworth - University of MichiganRyan C Bailey - University of MichiganJennifer R Bermick - Division of Neonatology, Department of Pediatrics, University of Iowa, Iowa City, IA, USA. jennifer-bermick@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Journal of perinatology, Vol.43(6), pp.758-765
- DOI
- 10.1038/s41372-022-01584-2
- PMID
- 36539561
- PMCID
- PMC10258137
- NLM abbreviation
- J Perinatol
- ISSN
- 0743-8346
- eISSN
- 1476-5543
- Grant note
- AI141673 / U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
- Language
- English
- Electronic publication date
- 12/20/2022
- Date published
- 06/2023
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984354512702771
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