Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy

Jaeyong Cho; Yoji Tsugawa; Yumi Imai; Takeshi Imai

doi:10.1016/j.bbrc.2021.09.039

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Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy

Journal article

Open access

Peer reviewed

Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy

Jaeyong Cho, Yoji Tsugawa, Yumi Imai and Takeshi Imai

Biochemical and biophysical research communications, Vol.579, pp.110-115

11/19/2021

DOI: 10.1016/j.bbrc.2021.09.039

PMCID: PMC8568302

PMID: 34597993

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Abstract

The liver increases its size during pregnancy to adapt to metabolic demand associated with pregnancy. Our previous study showed that proliferation of maternal hepatocytes are increased during pregnancy in mice and that estradiol (E2) is one of the candidate hormones responsible for maternal hepatocyte proliferation. Here, we discovered that chorionic gonadotropin (CG) induces maternal hepatocyte proliferation during pregnancy. CG administration was sufficient to stimulate hepatocyte proliferation in non-pregnant mice as well as in cell culture system. We conclude that CG stimulates proliferation in the early pregnancy of maternal hepatocytes. In contrast, estrogen stimulates hepatocyte proliferation in the late pregnancy. [Display omitted] •CG is the major maternal hepatocyte proliferator during pregnancy.•CG binds to LH/CGR for maternal proliferation.•Impaired CG-induced hepatocyte proliferation in aged mice.

Apoptosis

Pregnancy

Chorionic gonadotropin

Estrogen

Estrogen receptor

Hepatocyte

Placental lactogen

Ploidy

Details

Title: Subtitle: Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy
Creators: Jaeyong Cho - National Center for Geriatrics and Gerontology
Yoji Tsugawa - National Center for Geriatrics and Gerontology
Yumi Imai - University of Iowa
Takeshi Imai - National Center for Geriatrics and Gerontology
Resource Type: Journal article
Publication Details: Biochemical and biophysical research communications, Vol.579, pp.110-115
DOI: 10.1016/j.bbrc.2021.09.039
PMID: 34597993
PMCID: PMC8568302
NLM abbreviation: Biochem Biophys Res Commun
ISSN: 0006-291X
eISSN: 1090-2104
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/501100002241, name: Japan Science and Technology Agency; DOI: 10.13039/501100007312, name: National Center for Geriatrics and Gerontology, award: 19–27; DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/501100009029, name: JST Adaptable and Seamless Technology Transfer Program Through Target-driven R and D; DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases, award: R01-DK090490; DOI: 10.13039/501100009036, name: Strategic International Collaborative Research Program, award: FY2013–SICP; DOI: 10.13039/100000738, name: U.S. Department of Veterans Affairs, award: I01 BX005107; DOI: 10.13039/501100001700, name: Ministry of Education, Culture, Sports, Science and Technology; DOI: 10.13039/501100001691, name: Japan Society for the Promotion of Science, award: 18659493
Language: English
Date published: 11/19/2021
Academic Unit: Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984359894502771

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