Journal article
Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy
Biochemical and biophysical research communications, Vol.579, pp.110-115
11/19/2021
DOI: 10.1016/j.bbrc.2021.09.039
PMCID: PMC8568302
PMID: 34597993
Abstract
The liver increases its size during pregnancy to adapt to metabolic demand associated with pregnancy. Our previous study showed that proliferation of maternal hepatocytes are increased during pregnancy in mice and that estradiol (E2) is one of the candidate hormones responsible for maternal hepatocyte proliferation. Here, we discovered that chorionic gonadotropin (CG) induces maternal hepatocyte proliferation during pregnancy. CG administration was sufficient to stimulate hepatocyte proliferation in non-pregnant mice as well as in cell culture system. We conclude that CG stimulates proliferation in the early pregnancy of maternal hepatocytes. In contrast, estrogen stimulates hepatocyte proliferation in the late pregnancy.
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•CG is the major maternal hepatocyte proliferator during pregnancy.•CG binds to LH/CGR for maternal proliferation.•Impaired CG-induced hepatocyte proliferation in aged mice.
Details
- Title: Subtitle
- Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy
- Creators
- Jaeyong Cho - National Center for Geriatrics and GerontologyYoji Tsugawa - National Center for Geriatrics and GerontologyYumi Imai - University of IowaTakeshi Imai - National Center for Geriatrics and Gerontology
- Resource Type
- Journal article
- Publication Details
- Biochemical and biophysical research communications, Vol.579, pp.110-115
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.bbrc.2021.09.039
- PMID
- 34597993
- PMCID
- PMC8568302
- ISSN
- 0006-291X
- eISSN
- 1090-2104
- Grant note
- DOI: 10.13039/501100002241, name: Japan Science and Technology Agency; DOI: 10.13039/501100007312, name: National Center for Geriatrics and Gerontology, award: 19–27; DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/501100009029, name: JST Adaptable and Seamless Technology Transfer Program Through Target-driven R and D; DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases, award: R01-DK090490; DOI: 10.13039/501100009036, name: Strategic International Collaborative Research Program, award: FY2013–SICP; DOI: 10.13039/100000738, name: U.S. Department of Veterans Affairs, award: I01 BX005107; DOI: 10.13039/501100001700, name: Ministry of Education, Culture, Sports, Science and Technology; DOI: 10.13039/501100001691, name: Japan Society for the Promotion of Science, award: 18659493
- Language
- English
- Date published
- 11/19/2021
- Academic Unit
- Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984359894502771
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