Choroidal neovascularization secondary to Candida albicans chorioretinitis

L M Jampol; J Sung; J D Walker; J C Folk; W A Townsend-Pico; C Y Lowder; E M Dodds; D Westrich; J Terry

doi:10.1016/S0002-9394(14)70630-0

Back

Choroidal neovascularization secondary to Candida albicans chorioretinitis

Journal article

Peer reviewed

Choroidal neovascularization secondary to Candida albicans chorioretinitis

L M Jampol, J Sung, J D Walker, J C Folk, W A Townsend-Pico, C Y Lowder, E M Dodds, D Westrich and J Terry

American journal of ophthalmology, Vol.121(6), pp.643-649

06/1996

DOI: 10.1016/S0002-9394(14)70630-0

PMID: 8644807

View Online

Abstract

To study the clinical histories and courses of six patients with choroidal neovascularization secondary to endogenous Candida albicans chorioretinitis. The medical records, fundus photographs, and fluorescein angiograms of six patients who developed C. albicans chorioretinitis secondary to candidemia and who subsequently developed choroidal neovascularization in one or both eyes were reviewed. The six patients ranged in age from 18 to 79 years. Four were women and two men; all but one showed evidence of bilateral chorioretinal scarring secondary to C. albicans chorioretinitis. All patients had been treated successfully with systemic antifungal therapy (amphotericin B). Two weeks to two years after the chorioretinitis, choroidal neovascularization developed in one eye (four cases) or both eyes (two cases). The neovascularization on initial examination was subfoveal in four eyes, extrafoveal in three eyes, and juxtafoveal in one eye. Laser photocoagulation was used in four of the eight involved eyes. In these cases, the active choroidal neovascularization was brought under control. In one eye, the patient had submacular surgery for excision of the choroidal neovascular membrane. Final visual acuities ranged from 20/20 to 20/200 in treated eyes and from 20/50 to 20/400 in untreated eyes. Choroidal neovascularization is a potential cause of late visual loss in patients who have had C. albicans sepsis and endogenous C. albicans chorioretinitis. Eyes that have chorioretinal scarring from C. albicans chorioretinitis should be watched for the development of choroidal neovascularization. Laser photocoagulation or perhaps surgical excision of the neovascular complex may be of benefit in selected cases.

Choroid - surgery

Humans

Middle Aged

Neovascularization, Pathologic - surgery

Male

Laser Coagulation

Eye Infections, Fungal - complications

Neovascularization, Pathologic - etiology

Antifungal Agents - therapeutic use

Candidiasis - drug therapy

Fungemia - drug therapy

Candida albicans - isolation & purification

Adult

Female

Chorioretinitis - microbiology

Neovascularization, Pathologic - microbiology

Fluorescein Angiography

Fungemia - etiology

Choroid - blood supply

Chorioretinitis - complications

Visual Acuity

Candidiasis - complications

Chorioretinitis - drug therapy

Eye Infections, Fungal - drug therapy

Adolescent

Aged

Amphotericin B - therapeutic use

Fundus Oculi

Details

Title: Subtitle: Choroidal neovascularization secondary to Candida albicans chorioretinitis
Creators: L M Jampol - Department of Ophthalmology, Northwestern University Medical School, Chicago, Illinois 60611, USA. 1-jampol@nwu.edu
J Sung
J D Walker
J C Folk
W A Townsend-Pico
C Y Lowder
E M Dodds
D Westrich
J Terry
Resource Type: Journal article
Publication Details: American journal of ophthalmology, Vol.121(6), pp.643-649
Publisher: United States
DOI: 10.1016/S0002-9394(14)70630-0
PMID: 8644807
ISSN: 0002-9394
eISSN: 1879-1891
Language: English
Date published: 06/1996
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9983979952102771

Metrics

28 Record Views

32 Times Cited - Web of Science