Journal article
Chromatin and epigenetics in aging biology
Genetics (Austin), Vol.230(1), iyaf055
05/08/2025
DOI: 10.1093/genetics/iyaf055
PMCID: PMC13031114
PMID: 40202900
Abstract
This book chapter will focus on modifications to chromatin itself, how chromatin modifications are regulated, and how these modifications are deciphered by the cell to impact aging. In this chapter, we will review how chromatin modifications change with age, examine how chromatin-modifying enzymes have been shown to regulate aging and healthspan, discuss how some of these epigenetic changes are triggered and how they can regulate the lifespan of the individual and its naïve descendants, and speculate on future directions for the field.
Details
- Title: Subtitle
- Chromatin and epigenetics in aging biology
- Creators
- Eric Lieberman Greer - Washington University in St. LouisSiu Sylvia Lee - Cornell UniversityVeena Prahlad - Roswell Park Comprehensive Cancer Center
- Resource Type
- Journal article
- Publication Details
- Genetics (Austin), Vol.230(1), iyaf055
- DOI
- 10.1093/genetics/iyaf055
- PMID
- 40202900
- PMCID
- PMC13031114
- NLM abbreviation
- Genetics
- ISSN
- 1943-2631
- eISSN
- 1943-2631
- Publisher
- Oxford Academic
- Grant note
- R01AG024425 / NIA NIH HHS R01MH126282 / NIMH NIH HHS
- Language
- English
- Electronic publication date
- 04/09/2025
- Date published
- 05/08/2025
- Academic Unit
- Biology
- Record Identifier
- 9984808567502771
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