Chromosomal instability and acquired drug resistance in multiple myeloma

Wang Wang; Yi Zhang; Ruini Chen; Zhidan Tian; Yongpin Zhai; Siegfried Janz; Chunyan Gu; Ye Yang

doi:10.18632/oncotarget.20829

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Chromosomal instability and acquired drug resistance in multiple myeloma

Journal article

Open access

Peer reviewed

Chromosomal instability and acquired drug resistance in multiple myeloma

Wang Wang, Yi Zhang, Ruini Chen, Zhidan Tian, Yongpin Zhai, Siegfried Janz, Chunyan Gu and Ye Yang

Oncotarget, Vol.8(44), pp.78234-78244

2017

DOI: 10.18632/oncotarget.20829

PMCID: PMC5652852

PMID: 29100463

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Abstract

Chromosomal instability (CIN) is an important hallmark of human cancer. CIN not only contributes to all stages of tumor development (initiation, promotion and progression) but also drives, in large measure, the acquisition of drug resistance by cancer cells. Although CIN is a cornerstone of the complex mutational architecture that underlies neoplastic cell development and tumor heterogeneity and has been tightly associated with treatment responses and survival of cancer patients, it may be one of the least understood features of the malignant phenotype in terms of genetic pathways and molecular mechanisms. Here we review new insights into the type of CIN seen in multiple myeloma (MM), a blood cancer of terminally differentiated, immunoglobulin-producing B-lymphocytes called plasma cells that remains incurable in the great majority of cases. We will consider bona fide myeloma CIN genes, methods for measuring CIN in myeloma cells, and novel approaches to CIN-targeted treatments of patients with myeloma. The new findings generate optimism that enhanced understanding of CIN will lead to the design and testing of new therapeutic strategies to overcome drug resistance in MM in the not-so-distant future.

Drug Resistance

multiple myeloma

Review

proliferation

chromosomal instability

Details

Title: Subtitle: Chromosomal instability and acquired drug resistance in multiple myeloma
Creators: Wang Wang - The Third Affiliated Hospital, Nanjing University of Chinese Medicine, Nanjing, 210023, China
Yi Zhang - Department of Burns and Plastic Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, China
Ruini Chen - School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, 210023, China
Zhidan Tian - Department of Pathology, Nanjing First Hospital, Nanjing, 210006, China
Yongpin Zhai - Department of Hematology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, 210002, China
Siegfried Janz - Department of Pathology, The University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, 52242, USA
Chunyan Gu - The Third Affiliated Hospital, Nanjing University of Chinese Medicine, Nanjing, 210023, China
Ye Yang - The Third Affiliated Hospital, Nanjing University of Chinese Medicine, Nanjing, 210023, China
Resource Type: Journal article
Publication Details: Oncotarget, Vol.8(44), pp.78234-78244
DOI: 10.18632/oncotarget.20829
PMID: 29100463
PMCID: PMC5652852
NLM abbreviation: Oncotarget
ISSN: 1949-2553
eISSN: 1949-2553
Publisher: Impact Journals LLC
Language: English
Date published: 2017
Academic Unit: Pathology
Record Identifier: 9984083889902771

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