Chromosomal localization of the human gene for annexin V (placental anticoagulant protein I) to 4q26→q28

J. F TAIT; D. A FRANKENBERRY; R SHIANG; J. C MURRAY; D. A ADLER; C. M DISTECHE

doi:10.1159/000133143

Back

Chromosomal localization of the human gene for annexin V (placental anticoagulant protein I) to 4q26→q28

Journal article

Peer reviewed

Chromosomal localization of the human gene for annexin V (placental anticoagulant protein I) to 4q26→q28

J. F TAIT, D. A FRANKENBERRY, R SHIANG, J. C MURRAY, D. A ADLER and C. M DISTECHE

Cytogenetics and cell genetics, Vol.57(4), pp.187-192

1991

DOI: 10.1159/000133143

PMID: 1683830

View Online

Abstract

Annexin V is a member of a new family of calcium-dependent phospholipid-binding proteins. It has been previously isolated as placental anticoagulant protein I, inhibitor of blood coagulation, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4, and anchorin CII. The human gene encoding annexin V (ANX5) was localized to 4q26----q28 by in situ hybridization with a cDNA probe and polymerase chain-reaction (PCR) analysis of a human x hamster hybrid cell panel. The regional localization to 4q26----q28 was supported by Southern-blot analysis of a human cell line with a deletion in 4q23----q27. This localization overlaps but differs slightly from the previous assignment of ANX5 to 4q28----q32. Digestion with PvuII and TaqI identified polymorphisms at the ANX5 locus; the PvuII polymorphism could also be detected by PCR analysis.

Fundamental and applied biological sciences. Psychology

Classical genetics, quantitative genetics, hybrids

Human

Biological and medical sciences

Genetics of eukaryotes. Biological and molecular evolution

Details

Title: Subtitle: Chromosomal localization of the human gene for annexin V (placental anticoagulant protein I) to 4q26→q28
Creators: J. F TAIT - Univ. Washington, dep. lab. medicine, Seattle WA 98195, United States
D. A FRANKENBERRY - Univ. Washington, dep. lab. medicine, Seattle WA 98195, United States
R SHIANG - Univ. Washington, dep. lab. medicine, Seattle WA 98195, United States
J. C MURRAY - Univ. Washington, dep. lab. medicine, Seattle WA 98195, United States
D. A ADLER - Univ. Washington, dep. lab. medicine, Seattle WA 98195, United States
C. M DISTECHE - Univ. Washington, dep. lab. medicine, Seattle WA 98195, United States
Resource Type: Journal article
Publication Details: Cytogenetics and cell genetics, Vol.57(4), pp.187-192
DOI: 10.1159/000133143
PMID: 1683830
NLM abbreviation: Cytogenet Cell Genet
ISSN: 0301-0171
eISSN: 1424-859X
Publisher: Karger; Freiburg; Basel; Paris
Language: English
Date published: 1991
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
Record Identifier: 9984025671702771

Metrics

14 Record Views

21 Times Cited - Web of Science

See more details