Journal article
Chronic β-adrenergic activation-induced left ventricular systolic dysfunction is associated with systemic release of TNF-α and IL-1-β in rats
Pharmacological reports, Vol.61(5), pp.870-876
09/2009
DOI: 10.1016/S1734-1140(09)70143-4
PMID: 19904010
Abstract
The relationship between systemic cytokine release and chronic β-adrenergic activation-induced left ventricular dysfunction (LVSD) has not been widely reported in the literature. In the present study, we examined changes in the serum levels of inflammatory cytokines (IL-l-β, IL-6 and TNF-α) following chronic β-adrenergic activation-induced LVSD. Male Wistar rats were administered isoproterenol (ISO, 5mg/kg,sc once daily) for 4 weeks (ISO 4) or 12 weeks (ISO 12). Echocardiography was done and serum levels of IL - 1- β, IL-6 and TNF-α were estimated at the end of each protocol. In the ISO 4 group there was a significant increase in relative wall thickness (p<0.01) and heart weight: body weight ratio (p<0.001) without any significant changes in fractional shortening (FS) or serum cytokine levels. However, in the ISO 12 group, there was a 32% decrease in FS along with increased serum levels of IL-l-β and TNF-α. The present findings indicate that LVSD induced by chronic β-adrenergic activation in rats is accompanied by increased serum cytokine levels.
Details
- Title: Subtitle
- Chronic β-adrenergic activation-induced left ventricular systolic dysfunction is associated with systemic release of TNF-α and IL-1-β in rats
- Creators
- Santosh Kumar - All India Institute of Medical SciencesSandeep Seth - All India Institute of Medical SciencesAmardeep Jaiswal - All India Institute of Medical SciencesRajesh Enjamoori - All India Institute of Medical SciencesAmit K. Dinda - All India Institute of Medical SciencesRuma Ray - All India Institute of Medical SciencesSubir K. Maulik - All India Institute of Medical Sciences
- Resource Type
- Journal article
- Publication Details
- Pharmacological reports, Vol.61(5), pp.870-876
- Publisher
- Elsevier Urban & Partner Sp. z o.o
- DOI
- 10.1016/S1734-1140(09)70143-4
- PMID
- 19904010
- ISSN
- 1734-1140
- eISSN
- 2299-5684
- Language
- English
- Date published
- 09/2009
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984359771302771
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