Chronic Lung Disease as a Risk Factor for Long COVID in Patients Diagnosed With Coronavirus Disease 2019: A Retrospective Cohort Study

Xiaotong Zhang; Alfred Jerrod Anzalone; Daisy Dai; Gary Cochran; Ran Dai; Mark E Rupp; Adam B Wilcox; Adam M Lee; Alexis Graves; Amin Manna; Amit Saha; Amy Olex; Andrea Zhou; Andrew E Williams; Andrew Southerland; Andrew T Girvin; Anita Walden; Anjali A Sharathkumar; Benjamin Amor; Benjamin Bates; Brian Hendricks; Brijesh Patel; Caleb Alexander; Carolyn Bramante; Cavin Ward-Caviness; Charisse Madlock-Brown; Christine Suver; Christopher Chute; Christopher Dillon; Chunlei Wu; Clare Schmitt; Cliff Takemoto; Dan Housman; Davera Gabriel; David A Eichmann; Diego Mazzotti; Don Brown; Eilis Boudreau; Elaine Hill; Elizabeth Zampino; Emily Carlson Marti; Emily R Pfaff; Evan French; Farrukh M Koraishy; Federico Mariona; Fred Prior; George Sokos; Greg Martin; Harold Lehmann; Heidi Spratt; Hemalkumar Mehta; Hongfang Liu; Hythem Sidky; J.W. Awori Hayanga; Jami Pincavitch; Jaylyn Clark; Jeremy Richard Harper; Jessica Islam; Jin Ge; Joel Gagnier; Joel H Saltz; Johanna Loomba; John Buse; Jomol Mathew; Joni L Rutter; Julie A McMurry; Justin Guinney; Justin Starren; Karen Crowley; Katie Rebecca Bradwell; Kellie M Walters; Ken Wilkins; Kenneth R Gersing; Kenrick Dwain Cato; Kimberly Murray; Kristin Kostka; Lavance Northington; Lee Allan Pyles; Leonie Misquitta; Lesley Cottrell; Lili Portilla; Mariam Deacy; Mark M Bissell; Marshall Clark; Mary Emmett; Mary Morrison Saltz; Matvey B Palchuk; Melissa A Haendel; Meredith Adams; Meredith Temple-O’Connor; Michael G Kurilla; Michele Morris; Nabeel Qureshi; Nasia Safdar; Nicole Garbarini; Noha Sharafeldin; Ofer Sadan; Patricia A Francis; Penny Wung Burgoon; Peter Robinson; Philip R O Payne; Rafael Fuentes; Randeep Jawa; Rebecca Erwin-Cohen; Rena Patel; Richard A Moffitt; Richard L Zhu; Rishi Kamaleswaran; Robert Hurley; Robert T Miller; Saiju Pyarajan; Sam G Michael; Samuel Bozzette; Sandeep Mallipattu; Satyanarayana Vedula; Scott Chapman; Shawn T O’Neil; Soko Setoguchi; Steve Johnson; Stephanie S Hong; Tellen D Bennett; Tiffany Callahan; Umit Topaloglu; Usman Sheikh; Valery Gordon; Vignesh Subbian; Warren A Kibbe; Wenndy Hernandez; Will Beasley; Will Cooper; William Hillegass; Xiaohan Tanner Zhang; National COVID Cohort (N3C) Collaborative

doi:10.1093/ofid/ofae424

Back

Chronic Lung Disease as a Risk Factor for Long COVID in Patients Diagnosed With Coronavirus Disease 2019: A Retrospective Cohort Study

Journal article

Open access

Peer reviewed

Chronic Lung Disease as a Risk Factor for Long COVID in Patients Diagnosed With Coronavirus Disease 2019: A Retrospective Cohort Study

Xiaotong Zhang, Alfred Jerrod Anzalone, Daisy Dai, Gary Cochran, Ran Dai, Mark E Rupp, Adam B Wilcox, Adam M Lee, Alexis Graves, Amin Manna, …

Open forum infectious diseases, Vol.11(8), ofae424

08/01/2024

DOI: 10.1093/ofid/ofae424

PMCID: PMC11342242

PMID: 39183811

Files and links (1)

url

https://doi.org/10.1093/ofid/ofae424View

Published (Version of record) Open Access

Abstract

Abstract Background Patients with coronavirus disease 2019 (COVID-19) often experience persistent symptoms, known as postacute sequelae of COVID-19 or long COVID, after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Chronic lung disease (CLD) has been identified in small-scale studies as a potential risk factor for long COVID. Methods This large-scale retrospective cohort study using the National COVID Cohort Collaborative data evaluated the link between CLD and long COVID over 6 months after acute SARS-CoV-2 infection. We included adults (aged ≥18 years) who tested positive for SARS-CoV-2 during any of 3 SARS-CoV-2 variant periods and used logistic regression to determine the association, considering a comprehensive list of potential confounding factors, including demographics, comorbidities, socioeconomic conditions, geographical influences, and medication. Results Of 1 206 021 patients, 1.2% were diagnosed with long COVID. A significant association was found between preexisting CLD and long COVID (adjusted odds ratio [aOR], 1.36). Preexisting obesity and depression were also associated with increased long COVID risk (aOR, 1.32 for obesity and 1.29 for depression) as well as demographic factors including female sex (aOR, 1.09) and older age (aOR, 1.79 for age group 40–65 [vs 18–39] years and 1.56 for >65 [vs 18–39] years). Conclusions CLD is associated with higher odds of developing long COVID within 6 months after acute SARS-CoV-2 infection. These data have implications for identifying high-risk patients and developing interventions for long COVID in patients with CLD.

chronic lung disease

long COVID

SARS-CoV-2 infection

postacute sequelae of COVID

long COVID risk factor

Details

Title: Subtitle: Chronic Lung Disease as a Risk Factor for Long COVID in Patients Diagnosed With Coronavirus Disease 2019: A Retrospective Cohort Study
Creators: Xiaotong Zhang
Alfred Jerrod Anzalone
Daisy Dai
Gary Cochran
Ran Dai
Mark E Rupp
Adam B Wilcox
Adam M Lee
Alexis Graves
Amin Manna
Amit Saha
Amy Olex
Andrea Zhou
Andrew E Williams
Andrew Southerland
Andrew T Girvin
Anita Walden
Anjali A Sharathkumar
Benjamin Amor
Benjamin Bates
Brian Hendricks
Brijesh Patel
Caleb Alexander
Carolyn Bramante
Cavin Ward-Caviness
Charisse Madlock-Brown
Christine Suver
Christopher Chute
Christopher Dillon
Chunlei Wu
Clare Schmitt
Cliff Takemoto
Dan Housman
Davera Gabriel
David A Eichmann
Diego Mazzotti
Don Brown
Eilis Boudreau
Elaine Hill
Elizabeth Zampino
Emily Carlson Marti
Emily R Pfaff
Evan French
Farrukh M Koraishy
Federico Mariona
Fred Prior
George Sokos
Greg Martin
Harold Lehmann
Heidi Spratt
Hemalkumar Mehta
Hongfang Liu
Hythem Sidky
J.W. Awori Hayanga
Jami Pincavitch
Jaylyn Clark
Jeremy Richard Harper
Jessica Islam
Jin Ge
Joel Gagnier
Joel H Saltz
Johanna Loomba
John Buse
Jomol Mathew
Joni L Rutter
Julie A McMurry
Justin Guinney
Justin Starren
Karen Crowley
Katie Rebecca Bradwell
Kellie M Walters
Ken Wilkins
Kenneth R Gersing
Kenrick Dwain Cato
Kimberly Murray
Kristin Kostka
Lavance Northington
Lee Allan Pyles
Leonie Misquitta
Lesley Cottrell
Lili Portilla
Mariam Deacy
Mark M Bissell
Marshall Clark
Mary Emmett
Mary Morrison Saltz
Matvey B Palchuk
Melissa A Haendel
Meredith Adams
Meredith Temple-O’Connor
Michael G Kurilla
Michele Morris
Nabeel Qureshi
Nasia Safdar
Nicole Garbarini
Noha Sharafeldin
Ofer Sadan
Patricia A Francis
Penny Wung Burgoon
Peter Robinson
Philip R O Payne
Rafael Fuentes
Randeep Jawa
Rebecca Erwin-Cohen
Rena Patel
Richard A Moffitt
Richard L Zhu
Rishi Kamaleswaran
Robert Hurley
Robert T Miller
Saiju Pyarajan
Sam G Michael
Samuel Bozzette
Sandeep Mallipattu
Satyanarayana Vedula
Scott Chapman
Shawn T O’Neil
Soko Setoguchi
Steve Johnson
Stephanie S Hong
Tellen D Bennett
Tiffany Callahan
Umit Topaloglu
Usman Sheikh
Valery Gordon
Vignesh Subbian
Warren A Kibbe
Wenndy Hernandez
Will Beasley
Will Cooper
William Hillegass
Xiaohan Tanner Zhang
National COVID Cohort (N3C) Collaborative
Resource Type: Journal article
Publication Details: Open forum infectious diseases, Vol.11(8), ofae424
DOI: 10.1093/ofid/ofae424
PMID: 39183811
PMCID: PMC11342242
NLM abbreviation: Open Forum Infect Dis
ISSN: 2328-8957
eISSN: 2328-8957
Publisher: OXFORD UNIV PRESS INC
Grant note: NCATS: U24 TR002306, NCATS-P00438-B National Institute of General Medical Sciences: U54 GM115458, U54GM10494
The analyses described in this publication were conducted with data or tools accessed through the NCATS N3C Data Enclave (https://covid.cd2h.org) and N3C Attribution and Publication Policy v 1.2-2020-08-25b supported by NCATS (U24 TR002306, Axle Informatics Subcontract: NCATS-P00438-B), and the National Institute of General Medical Sciences (U54 GM115458 and U54GM104942), which funds the Great Plains IDeA-CTR Network, GP-CTR Health Informatics Research Scholar Program, and the West Virginia Clinical and Translational Science Institute.
Language: English
Date published: 08/01/2024
Academic Unit: School of Library and Information Science; Stead Family Department of Pediatrics; Hematology/Oncology; Nursing
Record Identifier: 9984699052402771

Metrics

63 Record Views

1 Times Cited - Web of Science