Journal article
Chronic Microelectrode Investigations of Normal Human Brain Physiology Using a Hybrid Depth Electrode
Stereotactic and functional neurosurgery, Vol.68(1-4), pp.236-242
1997
DOI: 10.1159/000099931
PMID: 9711723
Abstract
Neurosurgeons have unique access to in vivo human brain tissue, and in the course of clinical treatment important scientific advances have been made that further our understanding of normal brain physiology. In the modern era, microelectrode recordings have been used to systematically investigate the cellular properties of lateral temporal cerebral cortex. The current report describes a hybrid depth electrode (HDE) recording technique that was developed to enable neurosurgeons to simultaneously investigate normal cellular physiology during chronic intracranial EEG recordings. The HDE combines microelectrode and EEG recordings sites on a single shaft. Multiple microelectrode recordings are obtained from MRI defined brain sites and single-unit activity is discriminated from these data. To date, over 60 HDEs have been placed in 20 epilepsy surgery patients. Unique physiologic data have been gathered from neurons in numerous brain regions, including amygdala, hippocampus, frontal lobe, insula and Heschl’s gyrus. Functional activation studies were carried out without risking patient safety or comfort.
Details
- Title: Subtitle
- Chronic Microelectrode Investigations of Normal Human Brain Physiology Using a Hybrid Depth Electrode
- Creators
- Matthew A HowardIgor O VolkovM. Daniel NohMark A GrannerRoman MirskyP. Charles Garell
- Resource Type
- Journal article
- Publication Details
- Stereotactic and functional neurosurgery, Vol.68(1-4), pp.236-242
- Publisher
- Basel, Switzerland
- DOI
- 10.1159/000099931
- PMID
- 9711723
- eISBN
- 3318003050; 9783318003055
- ISSN
- 1011-6125
- eISSN
- 1423-0372
- Number of pages
- 7
- Language
- English
- Date published
- 1997
- Academic Unit
- Neurology; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984020628202771
Metrics
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