Journal article
Chronic Nonbacterial Osteomyelitis and Chronic Recurrent Multifocal Osteomyelitis in Children
The Pediatric clinics of North America, Vol.65(4), pp.783-800
08/2018
DOI: 10.1016/j.pcl.2018.04.003
PMID: 30031498
Abstract
Chronic nonbacterial osteomyelitis (CNO) is an innate immune system disorder that predominantly affects children. It can present as part of a syndrome or in isolation. It presents as bone pain with or without fever or objective swelling at the site. It is difficult to diagnose. Laboratory studies can be normal, whereas a biopsy reveals sterile osteomyelitis. Osteolytic or sclerotic bone changes may be seen on radiographs. However, MRI is more sensitive for detecting CNO and is considered the gold standard for monitoring the disease. Treatment depends on disease severity and includes nonsteroidal antiinflammatory drugs, bisphosphonates, and cytokine inhibitors.
Details
- Title: Subtitle
- Chronic Nonbacterial Osteomyelitis and Chronic Recurrent Multifocal Osteomyelitis in Children
- Creators
- Yongdong Zhao - Pediatric Rheumatology, Seattle Children's Hospital, University of Washington, MA 7.110, 4800 Sand Point Way Northeast, Seattle, WA 98105, USAPolly J Ferguson - Department of Pediatrics, University of Iowa Carver College of Medicine, 200 Hawkins Drive, 4038 Boyd Tower, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- The Pediatric clinics of North America, Vol.65(4), pp.783-800
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.pcl.2018.04.003
- PMID
- 30031498
- ISSN
- 0031-3955
- eISSN
- 1557-8240
- Grant note
- CARRA R01AR059703 / NIH/NIAMS IM101-691_Zhao / Bristol-Myers Squibb (https://doi.org/10.13039/100002491)
- Language
- English
- Date published
- 08/2018
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Rheumatology, Allergy, and Immunology
- Record Identifier
- 9984070830202771
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