Journal article
Chronic Pancreatitis: Pediatric and Adult Cohorts Show Similarities in Disease Progress Despite Different Risk Factors
Journal of pediatric gastroenterology and nutrition, Vol.68(4), pp.566-573
04/2019
DOI: 10.1097/MPG.0000000000002279
PMCID: PMC6492264
PMID: 30897605
Abstract
The aim of the present study was to investigate the natural history of chronic pancreatitis (CP); patients in the North American Pancreatitis Study2 (NAPS2, adults) and INternational Study group of Pediatric Pancreatitis: In search for a cuRE (INSPPIRE, pediatric) were compared.
Demographics, risk factors, disease duration, management and outcomes of 224 children and 1063 adults were compared using appropriate statistical tests for categorical and continuous variables.
Alcohol was a risk in 53% of adults and 1% of children (P < 0.0001); tobacco in 50% of adults and 7% of children (P < 0.0001). Obstructive factors were more common in children (29% vs 19% in adults, P = 0.001). Genetic risk factors were found more often in children. Exocrine pancreatic insufficiency was similar (children 26% vs adult 33%, P = 0.107). Diabetes was more common in adults than children (36% vs 4% respectively, P < 0.0001). Median emergency room visits, hospitalizations, and missed days of work/school were similar across the cohorts. As a secondary analysis, NAPS2 subjects with childhood onset (NAPS2-CO) were compared with INSPPIRE subjects. These 2 cohorts were more similar than the total INSPPIRE and NAPS2 cohorts, including for genetic risk factors. The only risk factor significantly more common in the NAPS2-CO cohort compared with the INSPPIRE cohort was alcohol (9% NAPS2-CO vs 1% INSPPIRE cohorts, P = 0.011).
Despite disparity in age of onset, children and adults with CP exhibit similarity in demographics, CP treatment, and pain. Differences between groups in radiographic findings and diabetes prevalence may be related to differences in risk factors associated with disease and length of time of CP.
Details
- Title: Subtitle
- Chronic Pancreatitis: Pediatric and Adult Cohorts Show Similarities in Disease Progress Despite Different Risk Factors
- Creators
- Sarah J Schwarzenberg - University of Minnesota Masonic Children's Hospital, Minneapolis, MNAliye Uc - University of Iowa, Stead Family Children's HospitalBridget Zimmerman - Department of Biostatistics, University of Iowa, Iowa City, IAMichael Wilschanski - Hadassah Hebrew University Hospital, Jerusalem, IsraelC Mel Wilcox - Department of Medicine, University of Alabama Birmingham, Birmingham, ALDavid C Whitcomb - Palmetto Health, Columbia Gastroenterology Associates, Columbia, SCSteven L Werlin - Medical College of Wisconsin, Milwaukee, WIDavid Troendle - University of Texas Southwestern Medical School, Dallas, TXGong Tang - Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PAAdam Slivka - Department of MedicineVikesh K Singh - Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MDStuart Sherman - Department of Medicine, Indiana University, Indianapolis, INUzma Shah - Massachusetts General Hospital for Children, Harvard Medical School, Boston, MABimaljit S Sandhu - Richmond Gastroenterology Associates, St. Mary's Hospital, Richmond, VAJoseph Romagnuolo - Palmetto Health, Columbia Gastroenterology Associates, Columbia, SCSue Rhee - University of California San Francisco Benioff Children's Hospital, San Francisco, CAJohn F Pohl - University of Utah, Salt Lake City, UTEmily R Perito - University of California San Francisco Benioff Children's Hospital, San Francisco, CAChee Y Ooi - School of Women's and Children's Health, Medicine, University of New South Wales and Sydney Children's Hospital Randwick Sydney, AustraliaJaimie D Nathan - Cincinnati Children's Hospital Medical Center, Cincinnati, OHThiruvengadam Muniraj - Yale University, New Haven, CTVeronique D Morinville - Montreal Children's Hospital, McGill University, Montreal, Quebec, CanadaBrian McFerron - Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, INMaria Mascarenhas - Children's Hospital of Philadelphia, Philadelphia, PAAsim Maqbool - Children's Hospital of Philadelphia, Philadelphia, PAQuin Liu - Cedars-Sinai Medical Center, Los Angeles, CATom K Lin - Cincinnati Children's Hospital Medical Center, Cincinnati, OHMichele Lewis - Department of Medicine, Mayo Clinic, Jacksonville, FLSohail Z Husain - Children's Hospital of Pittsburgh, Pittsburgh, PARyan Himes - Baylor College of Medicine, Houston, TXMelvin B Heyman - University of California San Francisco Benioff Children's Hospital, San Francisco, CANalini Guda - Aurora Health Care, St. Luke's Medical Center, Milwaukee, WITanja Gonska - Hospital for Sick Children, Toronto, Ontario, CanadaMatthew J Giefer - Seattle Children's Hospital, Seattle, WAAndres Gelrud - GastroHealth, Miami, FLCheryl E Gariepy - Nationwide Children's Hospital, Columbus, OHTimothy B Gardner - Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NHSteven D Freedman - Harvard Medical School, Boston, MAChristopher E Forsmark - Department of Medicine, Medical University of South Carolina, Charleston, SCDouglas S Fishman - Baylor College of Medicine, Houston, TXGregory A Cote - Aurora Health Care, St. Luke's Medical Center, Milwaukee, WIDarwin Conwell - Department of Medicine, Ohio State University, Columbus, OHRandall E Brand - Department of MedicineMelena Bellin - University of Minnesota Masonic Children's Hospital, Minneapolis, MNBradley Barth - University of Texas Southwestern Medical School, Dallas, TXPeter A Banks - Department of Medicine, Brigham and Women's Hospital, Boston, MAMichelle A Anderson - Department of Medicine, University of Michigan, Ann Arbor, MIStephen T Amann - Digestive Health Specialists, Tupelo, MSSamer Alkaade - Department of Medicine, Saint Louis University, St. Louis, MOMaisam Abu-El-Haija - Cincinnati Children's Hospital Medical Center, Cincinnati, OHJudah N Abberbock - Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PAMark E Lowe - Washington University School of MedicineDhiraj Yadav - Department of Medicine
- Resource Type
- Journal article
- Publication Details
- Journal of pediatric gastroenterology and nutrition, Vol.68(4), pp.566-573
- DOI
- 10.1097/MPG.0000000000002279
- PMID
- 30897605
- PMCID
- PMC6492264
- NLM abbreviation
- J Pediatr Gastroenterol Nutr
- ISSN
- 0277-2116
- eISSN
- 1536-4801
- Grant note
- U01 DK108306 / NIDDK NIH HHS R01 DK077906 / NIDDK NIH HHS U01 DK108326 / NIDDK NIH HHS U01 DK108334 / NIDDK NIH HHS R01 DK061451 / NIDDK NIH HHS UL1 TR002538 / NCATS NIH HHS UL1 TR000005 / NCATS NIH HHS UL1 TR000442 / NCATS NIH HHS P30 CA086862 / NCI NIH HHS R21 DK096327 / NIDDK NIH HHS UL1 RR024153 / NCRR NIH HHS R01 DK097820 / NIDDK NIH HHS UL1 TR001863 / NCATS NIH HHS U01 DK108327 / NIDDK NIH HHS R56 DK061451 / NIDDK NIH HHS P30 DK054759 / NIDDK NIH HHS U01 DK108320 / NIDDK NIH HHS
- Language
- English
- Date published
- 04/2019
- Academic Unit
- Stead Family Department of Pediatrics; Biostatistics; Radiation Oncology; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9984214676802771
Metrics
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