Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop

Aliye Uc; Dana K Andersen; Melena D Bellin; Jason I Bruce; Asbjørn M Drewes; John F Engelhardt; Christopher E Forsmark; Markus M Lerch; Mark E Lowe; Brent A Neuschwander-Tetri; Stephen J O’Keefe; Tonya M Palermo; Pankaj Pasricha; Ashok K Saluja; Vikesh K Singh; Eva M Szigethy; David C Whitcomb; Dhiraj Yadav; Darwin L Conwell

doi:10.1097/MPA.0000000000000713

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Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop

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Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop

Aliye Uc, Dana K Andersen, Melena D Bellin, Jason I Bruce, Asbjørn M Drewes, John F Engelhardt, Christopher E Forsmark, Markus M Lerch, Mark E Lowe, Brent A Neuschwander-Tetri, …

Pancreas, Vol.45(10), pp.1365-1375

11/2016

DOI: 10.1097/MPA.0000000000000713

PMCID: PMC5117429

PMID: 27748719

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https://www.ncbi.nlm.nih.gov/pmc/articles/5117429View

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Abstract

A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to focus on research gaps and opportunities in chronic pancreatitis (CP) and its sequelae. This conference marked the 20 th year anniversary of the discovery of the cationic trypsinogen ( PRSS1) gene mutation for hereditary pancreatitis. The event was held on July 27, 2016, and structured into 4 sessions: (1) pathophysiology; (2) exocrine complications; (3) endocrine complications; and (4) pain. The current state of knowledge was reviewed; many knowledge gaps and research needs were identified that require further investigation. Common themes included the need to design better tools to diagnose CP and its sequelae early and reliably, identify predisposing risk factors for disease progression, develop standardized protocols to distinguish type 3c diabetes mellitus from other types of diabetes and design effective therapeutic strategies through novel cell culture technologies, animal models mimicking human disease, and pain management tools. Gene therapy and cystic fibrosis conductance regulator (CFTR) potentiators as possible treatments for CP were discussed. Importantly, the need for chronic pancreatitis endpoints and intermediate targets for future drug trials was emphasized.

Details

Title: Subtitle: Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop
Creators: Aliye Uc - Division of Gastroenterology, Hepatology, Nutrition, Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA
Dana K Andersen - The Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD
Melena D Bellin - Departments of Pediatrics and Surgery, University of Minnesota Medical School, Minneapolis, MN
Jason I Bruce - Faculty of Life Sciences, University of Manchester, UK
Asbjørn M Drewes - Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark
John F Engelhardt - Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA
Christopher E Forsmark - Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, Gainesville, FL
Markus M Lerch - Department of Medicine, University Medicine Greifswald, Greifswald, Germany
Mark E Lowe - Division of Gastroenterology, Hepatology, Nutrition, Department of Pediatrics, Children’s Hospital of Pittsburgh, Pittsburgh, PA
Brent A Neuschwander-Tetri - Division of Gastroenterology and Hepatology, Saint Louis University, Saint Louis, MO
Stephen J O’Keefe - Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA
Tonya M Palermo - Center for Child Health, Behavior, and Development, Seattle Children’s Research Institute, University of Washington, Seattle, WA
Pankaj Pasricha - Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
Ashok K Saluja - Department of Surgery, University of Miami Miller School of Medicine, Miami, FL
Vikesh K Singh - Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
Eva M Szigethy - Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA
David C Whitcomb - Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA
Dhiraj Yadav - Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA
Darwin L Conwell - Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio
Resource Type: Journal article
Publication Details: Pancreas, Vol.45(10), pp.1365-1375
DOI: 10.1097/MPA.0000000000000713
PMID: 27748719
PMCID: PMC5117429
NLM abbreviation: Pancreas
ISSN: 0885-3177
eISSN: 1536-4828
Language: English
Date published: 11/2016
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Radiation Oncology; Gastroenterology, Hepatology, Pancreatology, and Nutrition; Internal Medicine
Record Identifier: 9984025371702771

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