Journal article
Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment
Current osteoporosis reports, Vol.15(6), pp.542-554
12/2017
DOI: 10.1007/s11914-017-0405-9
PMCID: PMC5705736
PMID: 29080202
Abstract
Chronic non-bacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disorder. We summarize the clinical presentation, diagnostic approaches, most recent advances in understanding the pathophysiology, and available treatment options and outcomes in CNO/CRMO.
Though the exact molecular pathophysiology of CNO/CRMO remains somewhat elusive, it appears likely that variable defects in the TLR4/MAPK/inflammasome signaling cascade result in an imbalance between pro- and anti-inflammatory cytokine expressions in monocytes from CNO/CRMO patients. In this context, we present previously unpublished data on cytokine and chemokine expression in monocytes and tissues. CNO/CRMO is an autoinflammatory bone disorder resulting from imbalanced cytokine expression from innate immune cells. Though the exact molecular pathophysiology remains unclear, variable molecular defects appear to result in inflammasome activation and pro-inflammatory cytokine expression in monocytes from CNO/CRMO patients. Recent advances suggest signaling pathways and single molecules as biomarkers for CNO/CRMO as well as future treatment targets.
Details
- Title: Subtitle
- Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment
- Creators
- Sigrun R Hofmann - Pediatric Rheumatology and Immunology, Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, GermanyFranz Kapplusch - Pediatric Rheumatology and Immunology, Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, GermanyHermann J Girschick - Vivantes Klinikum Friedrichshain, Children's Hospital, Berlin, GermanyHenner Morbach - Pediatric Rheumatology and Immunology, Children's Hospital, University of Würzburg, Würzburg, GermanyJessica Pablik - Division of Pathology, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, GermanyPolly J Ferguson - Department of Pediatrics, University of Iowa Stead Family Children's Hospital, Iowa City, IA, USAChristian M Hedrich - Department of Pediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, UK. Christian.hedrich@liverpool.ac.uk
- Resource Type
- Journal article
- Publication Details
- Current osteoporosis reports, Vol.15(6), pp.542-554
- DOI
- 10.1007/s11914-017-0405-9
- PMID
- 29080202
- PMCID
- PMC5705736
- NLM abbreviation
- Curr Osteoporos Rep
- ISSN
- 1544-1873
- eISSN
- 1544-2241
- Publisher
- United States
- Grant note
- DOI: 10.13039/501100000836, name: University of Liverpool
- Language
- English
- Date published
- 12/2017
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Rheumatology, Allergy, and Immunology
- Record Identifier
- 9984070542402771
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