Chronic Recurrent Multifocal Osteomyelitis and Related Diseases-Update on Pathogenesis

Allison J Cox; Yongdong Zhao; Polly J Ferguson

doi:10.1007/s11926-017-0645-9

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Journal article

Chronic Recurrent Multifocal Osteomyelitis and Related Diseases-Update on Pathogenesis

Allison J Cox, Yongdong Zhao and Polly J Ferguson

Current rheumatology reports, Vol.19(4), pp.18-6

04/2017

DOI: 10.1007/s11926-017-0645-9

PMCID: PMC5545929

PMID: 28361334

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Abstract

We focus on recent advances in the understanding of the genetic, molecular, immunologic, and environmental factors implicated in the pathogenesis of autoinflammatory bone diseases including the syndromic and non-syndromic forms of chronic recurrent multifocal osteomyelitis (CRMO).\nEvidence implicating the IL-1 pathway in the pathogenesis of the Mendelian forms of CRMO is growing. LIPIN2 can regulate the NLRP3 inflammasome by affecting P2X7 receptor activation, and intracellular cholesterol can modulate P2X7R currents. Work in a mouse model of CRMO demonstrates that dietary manipulation can alter the microbiome and protect these mice from the development of sterile osteomyelitis in vivo. Although the genetic and immunologic basis of non-syndromic CRMO remains only partially understood, the IL-1 pathway is central to the pathogenesis in the syndromic autoinflammatory bone disorders. Recent work implicates lipids and the microbiome in sterile osteomyelitis.

Cell Adhesion Molecules - genetics

Cytoskeletal Proteins - genetics

Humans

Hereditary Autoinflammatory Diseases - etiology

Inflammasomes - physiology

Microbiota

Osteomyelitis - etiology

Anemia, Dyserythropoietic, Congenital - etiology

Animals

Interleukin-1 - immunology

Mice

Nuclear Proteins - physiology

Disease Models, Animal

Details

Title: Subtitle: Chronic Recurrent Multifocal Osteomyelitis and Related Diseases-Update on Pathogenesis
Creators: Allison J Cox - Department of Pediatrics and the Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, IA, USA
Yongdong Zhao - Pediatric Rheumatology, Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA
Polly J Ferguson - Department of Pediatrics and the Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, IA, USA. polly-ferguson@uiowa.edu
Resource Type: Journal article
Publication Details: Current rheumatology reports, Vol.19(4), pp.18-6
DOI: 10.1007/s11926-017-0645-9
PMID: 28361334
PMCID: PMC5545929
NLM abbreviation: Curr Rheumatol Rep
ISSN: 1523-3774
eISSN: 1534-6307
Publisher: Springer Science and Business Media LLC; United States
Grant note: R01 AR059703 / NIAMS NIH HHS
Language: English
Date published: 04/2017
Academic Unit: Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Rheumatology, Allergy, and Immunology
Record Identifier: 9984070371402771

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