Journal article
Chronic Steroid Use is Not Associated with Increased Short-Term Morbidity After Distal Pancreatectomy: A Propensity-Matched Analysis
Surgery, 110606
09/03/2026
DOI: 10.1016/j.surg.2026.110606
Abstract
A national study analyzing the association between chronic steroid use and outcomes after pancreatic resection is lacking. This study aimed to evaluate the association between chronic glucocorticoid use and outcomes after distal pancreatectomy (DP) using a national database.
A retrospective analysis of patients undergoing DP was performed using the NSQIP database (2018-2024). In addition, we used propensity score matching to compare patients on chronic steroids with those who were not. The outcomes measured included 30-day complications and mortality, need for readmission, prolonged hospital stay, and pancreatic fistula.
Of the 6,876 patients who underwent DP, 623 were on chronic steroids. After propensity score matching, 438 patients in the steroid group and 876 patients in the non-steroid group were compared. There were no significant differences in pancreatic fistula (23.7% vs. 21.7%; p = 0.3), major complications (31.7% vs. 30.1%; p = 0.1), minor complications (42.2% vs. 41.6%; p = 0.6), mortality (3.4% vs. 3.2%; p = 0.6), readmission (15.8% vs. 14.7%; p = 0.3), or prolonged length of stay (11.4% vs. 10.5%; p = 0.5). On multivariate analysis, chronic steroid use was not independently associated with any adverse outcomes.
Chronic glucocorticoid use was not associated with increased short-term morbidity, pancreatic fistula, or mortality following DP. These findings suggest that chronic steroid dependence should not be considered a contraindication to DP, although the results should be interpreted with caution given the inability to assess dose-response relationships and the potential for residual confounding.
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Details
- Title: Subtitle
- Chronic Steroid Use is Not Associated with Increased Short-Term Morbidity After Distal Pancreatectomy: A Propensity-Matched Analysis
- Creators
- Sangrag Ganguli - University of ChicagoJason Z. Gao - University of IowaMohammed F. Almeflehi - University of IowaAmir Ebadinejad - University of IowaHassan Aziz - University of Iowa Health Care, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- Surgery, 110606
- DOI
- 10.1016/j.surg.2026.110606
- ISSN
- 0039-6060
- Publisher
- Elsevier Inc
- Language
- English
- Electronic publication date
- 09/03/2026
- Academic Unit
- Neurology; Surgery
- Record Identifier
- 9985224435302771
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