Journal article
Chronic Treatment With Polyethylene-Glycolated Superoxide Dismutase Partially Restores Endothelium-Dependent Vascular Relaxations in Cholesterol-Fed Rabbits
Circulation research, Vol.69(5), pp.1293-1300
11/1991
DOI: 10.1161/01.RES.69.5.1293
PMID: 1934359
Abstract
The endothelium-derived relaxing factor is rapidly inactivated by superoxide radicals, and atherosclerotic vessels generate excess radical species. We tested the hypothesis that an imbalance between intrinsic superoxide dismutase (SOD) activity and the generation of superoxide radicals in atherosclerotic arteries may result in augmented inactivation of endothelium-derived relaxing factor. Vascular SOD was increased in normal and cholesterol-fed (1% cholesterol for 4 months) rabbits approximately twofold by treatment with polyethylene-glycolated SOD (PEG-SOD; 41,000 units/kg/day i.m.) for 1 week. Aortic rings from these animals and nontreated control and atherosclerotic rabbits subsequently were studied in organ chambers. Endothelium-dependent relaxations to acetylcholine and the calcium ionophore A23187 were improved by PEG-SOD in atherosclerotic but not in normal rabbits. PEG-SOD pretreatment did not alter endothelium-independent relaxations to nitroprusside. Thus, treatment with PEG-SOD can partially restore impaired endothelium-dependent relaxation of atherosclerotic arteries. We conclude that generation of oxygen-derived radicals likely contributes to endothelial dysfunction of atherosclerotic arteries. (Circulation Research 1991;69:1293–1300)
Details
- Title: Subtitle
- Chronic Treatment With Polyethylene-Glycolated Superoxide Dismutase Partially Restores Endothelium-Dependent Vascular Relaxations in Cholesterol-Fed Rabbits
- Creators
- Andreas Mügge - Department of Internal Medicine, Cardiovascular Center, and Radiation Research Laboratory, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa CityJames ElwellTimothy PetersonTimothy HofmeyerDonald HeistadDavid Harrison
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.69(5), pp.1293-1300
- Publisher
- American Heart Association, Inc
- DOI
- 10.1161/01.RES.69.5.1293
- PMID
- 1934359
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Language
- English
- Date published
- 11/1991
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040325102771
Metrics
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