Journal article
Chronic Use of Aspirin and Total White Matter Lesion Volume: Results from the Women's Health Initiative Memory Study of Magnetic Resonance Imaging Study
Journal of stroke and cerebrovascular diseases, Vol.26(10), pp.2128-2136
10/2017
DOI: 10.1016/j.jstrokecerebrovasdis.2017.04.034
PMID: 28551293
Abstract
To investigate the relationship between aspirin and subclinical cerebrovascular heath, we evaluated the effect of chronic aspirin use on white matter lesions (WML) volume among women.
Chronic aspirin use was assessed in 1365 women who participated in the Women's Health Initiative Memory Study of Magnetic Resonance Imaging. Differences in WML volumes between aspirin users and nonusers were assessed with linear mixed models. A number of secondary analyses were performed, including lobe-specific analyses, subgroup analyses based on participants' overall risk of cerebrovascular disease, and a dose–response relationship analysis.
The mean age of the women at magnetic resonance imaging examination was 77.6 years. Sixty-one percent of participants were chronic aspirin users. After adjusting for demographic variables and comorbidities, chronic aspirin use was nonsignificantly associated with 4.8% (95% CI: −6.8%, 17.9%) larger WML volumes. These null findings were confirmed in secondary and sensitivity analyses, including an active comparator evaluation where aspirin users were compared to users of nonaspirin nonsteroidal anti-inflammatory drugs or acetaminophen.
There was a nonsignificant difference in WML volumes between aspirin users and nonusers. Further, our results suggest that chronic aspirin use may not have a clinically significant effect on WML volumes in women.
Details
- Title: Subtitle
- Chronic Use of Aspirin and Total White Matter Lesion Volume: Results from the Women's Health Initiative Memory Study of Magnetic Resonance Imaging Study
- Creators
- Andrea Holcombe - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IowaEric Ammann - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IowaMark A Espeland - Department of Biostatistical Sciences, School of Medicine, Wake Forest University, Winston-Salem, North CarolinaBrendan J Kelley - Department of Neurology, Wexner Medical Center, Ohio State University, Columbus, OhioJoAnn E Manson - Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MassachusettsRobert Wallace - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IowaJennifer Robinson - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of stroke and cerebrovascular diseases, Vol.26(10), pp.2128-2136
- DOI
- 10.1016/j.jstrokecerebrovasdis.2017.04.034
- PMID
- 28551293
- NLM abbreviation
- J Stroke Cerebrovasc Dis
- ISSN
- 1052-3057
- eISSN
- 1532-8511
- Publisher
- Elsevier Inc
- Grant note
- HHSN268201600018C; HHSN268201600001C; HHSN268201600002C; HHSN268201600003C; HHSN268201600004C / National Heart, Lung, and Blood Institute (http://dx.doi.org/10.13039/100000050) National Institutes of Health (http://dx.doi.org/10.13039/100000002) U.S. Department of Health and Human Services (http://dx.doi.org/10.13039/100000016)
- Language
- English
- Date published
- 10/2017
- Academic Unit
- Neurology; Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9983995160102771
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