Journal article
Chronic chlorpyrifos exposure does not promote prostate cancer in prostate specific PTEN mutant mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32(1), pp.29-39
2013
DOI: 10.1615/JEnvironPatholToxicolOncol.2013006778
PMCID: PMC3951157
PMID: 23758150
Abstract
Environmental factors are likely to interact with genetic determinants to influence prostate cancer progression. The Agricultural Health Study has identified an association between exposure to organophosphorous pesticides including chlorpyrifos, and increased prostate cancer risk in pesticide applicators with a first-degree family history of this disease. Exploration of this potential gene-environment interaction would benefit from the development of a suitable animal model. Utilizing a previously described mouse model that is genetically predisposed to prostate cancer through a prostate-specific heterozygous PTEN deletion, termed C57/Luc/Ptenp+/-, we used bioluminescence imaging and histopathological analyses to test whether chronic exposure to chlorpyrifos in a grain-based diet for 32 weeks was able to promote prostate cancer development. Chronic exposure to chlorpyrifos in the diet did not promote prostate cancer development in C57/Luc/Ptenp+/- mice despite achieving sufficient levels to inhibit acetylcholinesterase activity in plasma. We found no significant differences in numbers of murine prostatic intraepithelial neoplasia lesions or disease progression in chlorpyrifos versus control treated animals up to 32 weeks. The mechanistic basis of pesticide-induced prostate cancer may be complex and may involve other genetic variants, multiple genes, or nongenetic factors that might alter prostate cancer risk during pesticide exposure in agricultural workers.
Details
- Title: Subtitle
- Chronic chlorpyrifos exposure does not promote prostate cancer in prostate specific PTEN mutant mice
- Creators
- Robert U SvenssonNadine L BannickMaximo J MarinMichael D HenryLarry W RobertsonCharles F Lynch
- Resource Type
- Journal article
- Publication Details
- Journal of Environmental Pathology, Toxicology and Oncology, Vol.32(1), pp.29-39
- DOI
- 10.1615/JEnvironPatholToxicolOncol.2013006778
- PMID
- 23758150
- PMCID
- PMC3951157
- NLM abbreviation
- J Environ Pathol Toxicol Oncol
- ISSN
- 0731-8898
- eISSN
- 2162-6537
- Language
- English
- Date published
- 2013
- Academic Unit
- Molecular Physiology and Biophysics; Occupational and Environmental Health; Epidemiology; Pathology; Radiation Oncology; Urology
- Record Identifier
- 9983995032302771
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