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Chronic cutaneous lupus erythematosus in vitiligo
Journal article   Open access   Peer reviewed

Chronic cutaneous lupus erythematosus in vitiligo

Hillary Johnson, Nicole M Bossenbroek, Karla Rosenman, Shane A Meehan, Mirin Robles and Miriam K Pomeranz
Dermatology online journal, Vol.14(10), 10
10/15/2008
DOI: 10.5070/D34gc3n44x
PMID: 19061609
url
https://doi.org/10.5070/D34gc3n44xView
Published (Version of record) Open Access

Abstract

A 49-year-old woman presented with a seven-year history of pruritic, erythematous, scaling plaques on sun-exposed skin that localized only to pre-existing depigmented patches. Histopathologic examination showed changes consistent with cutaneous lupus erythematosus with lichenoid features and confirmed contiguous vitiligo. Diagnosis of chronic cutaneous lupus erythematosus localized to areas of vitiligo was determined by clinicopathologic correlation and may reflect an autoimmune diathesis. Consequently, hydroxychloroquine and topical glucocorticoids therapy were initiated with reported improvement in pruritus, erythema, and scale. Clinical monitoring for development of squamous-cell carcinoma in areas of chronic inflammation and sun-exposure is imperative.
 Autoimmunity Hydroxychloroquine - therapeutic use Vitiligo - complications Lupus Erythematosus, Discoid - drug therapy Skin Neoplasms - radiotherapy Humans Middle Aged Psoriasis - diagnosis Vitiligo - immunology Carcinoma, Squamous Cell - radiotherapy Ultraviolet Rays - adverse effects Skin Neoplasms - complications Lupus Erythematosus, Discoid - complications Fluocinolone Acetonide - therapeutic use Sunlight - adverse effects Diabetes Complications - immunology Diagnostic Errors Carcinoma, Squamous Cell - complications Photosensitivity Disorders - complications Female Lupus Erythematosus, Discoid - immunology Pruritus - etiology Drug Therapy, Combination Clobetasol - therapeutic use

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