Chronic graft-versus-host disease and the risk of primary disease relapse: A meta-analysis

Kittika Poonsombudlert; Jakarin Kewcharoen; Chanavuth Kanitsoraphan; Chattip Prueksapraopong; Nath Limpruttidham

doi:10.1016/j.exphem.2019.04.004

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Chronic graft-versus-host disease and the risk of primary disease relapse: A meta-analysis

Journal article

Open access

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Chronic graft-versus-host disease and the risk of primary disease relapse: A meta-analysis

Kittika Poonsombudlert, Jakarin Kewcharoen, Chanavuth Kanitsoraphan, Chattip Prueksapraopong and Nath Limpruttidham

Experimental hematology, Vol.74, pp.33-41

06/2019

DOI: 10.1016/j.exphem.2019.04.004

PMID: 31047963

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Abstract

Both primary disease relapse (PDR) and chronic graft-versus-host disease (cGVHD) have long been the dreaded outcomes for patients with hematologic malignancies. Previous theories have speculated an inverse relationship between the two; therefore, we attempted to verify the described association. We searched for titles of articles in MEDLINE (PubMed), Cochrane library, and EMBASE database that evaluated the association between PDR and cGVHD and conducted a random effect meta-analysis of 11 studies involving a total of 64,239 participants. We found a significantly decreased risk of developing PDR in patients with cGVHD, with a pooled risk ratio of 0.49 (95% confidence interval: 0.40-0.61, I  = 69.3%). We concluded that patients with cGVHD have a significantly lower risk of developing PDR compared with patients without cGVHD.

Chronic Disease

Female

Graft vs Host Disease - epidemiology

Graft vs Host Disease - etiology

Hematologic Neoplasms - epidemiology

Hematologic Neoplasms - therapy

Humans

Male

Recurrence

Risk Factors

Details

Title: Subtitle: Chronic graft-versus-host disease and the risk of primary disease relapse: A meta-analysis
Creators: Kittika Poonsombudlert - University of Hawaii System
Jakarin Kewcharoen - University of Hawaii System
Chanavuth Kanitsoraphan - University of Hawaii System
Chattip Prueksapraopong - Navamindradhiraj University
Nath Limpruttidham - University of Hawaii System
Resource Type: Journal article
Publication Details: Experimental hematology, Vol.74, pp.33-41
DOI: 10.1016/j.exphem.2019.04.004
PMID: 31047963
NLM abbreviation: Exp Hematol
ISSN: 0301-472X
eISSN: 1873-2399
Language: English
Date published: 06/2019
Academic Unit: Internal Medicine
Record Identifier: 9984694749502771

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