Chronic hepatitis E: A brief review

Arvind R Murali; Vikram Kotwal; Saurabh Chawla

doi:10.4254/wjh.v7.i19.2194

Back

Journal article

Open access

Peer reviewed

Chronic hepatitis E: A brief review

Arvind R Murali, Vikram Kotwal and Saurabh Chawla

World journal of hepatology, Vol.7(19), pp.2194-2201

09/08/2015

DOI: 10.4254/wjh.v7.i19.2194

PMCID: PMC4561773

PMID: 26380044

Files and links (1)

url

https://doi.org/10.4254/wjh.v7.i19.2194View

Published (Version of record) Open Access

Abstract

Hepatitis E viral infection has traditionally been considered an acute, self-limited, water borne disease similar to hepatitis A, endemic to developing countries. However, over the past decade, zoonotic transmission and progression to chronicity in human patients has been identified, resulting in persistently elevated transaminase levels, progressive liver injury and cirrhosis. In addition to liver injury, neurological, renal and rheumatological manifestations have also been reported. Chronic hepatitis E occurs mainly in immunosuppressed individuals such as transplant recipients, human immunodeficiency virus patients with low CD4 counts and in patients with hematological malignancies receiving chemotherapy. Diagnosis is established by persistent elevation of hepatitis E virus RNA in the stool or serum. This population often requires treatment with antiviral agents, particularly ribavirin, as spontaneous clearance with reduction in immunosuppression occurs only in about a third of the patients. The purpose of this review, is to further discuss the clinical presentation, and recent advances in diagnosis, treatment and prophylaxis of chronic hepatitis E.

Immunosuppression

Chronic liver disease

Solid organ transplantation

Hematological malignancies

Hepatitis E virus

Details

Title: Subtitle: Chronic hepatitis E: A brief review
Creators: Arvind R Murali - Arvind R Murali, Department of Gastroenterology and Hepatology, University of Iowa Hospitals and Clinics, Iowa City, IA 52246, United States
Vikram Kotwal - Arvind R Murali, Department of Gastroenterology and Hepatology, University of Iowa Hospitals and Clinics, Iowa City, IA 52246, United States
Saurabh Chawla - Arvind R Murali, Department of Gastroenterology and Hepatology, University of Iowa Hospitals and Clinics, Iowa City, IA 52246, United States
Resource Type: Journal article
Publication Details: World journal of hepatology, Vol.7(19), pp.2194-2201
DOI: 10.4254/wjh.v7.i19.2194
PMID: 26380044
PMCID: PMC4561773
NLM abbreviation: World J Hepatol
ISSN: 1948-5182
eISSN: 1948-5182
Language: English
Date published: 09/08/2015
Academic Unit: Gastroenterology and Hepatology; Internal Medicine
Record Identifier: 9984094360802771

Metrics

13 Record Views

54 Times Cited - Web of Science