Journal article
Chronic infection by Leishmania amazonensis mediated through MAPK ERK mechanisms
Immunologic research, Vol.59(1-3), pp.153-165
08/2014
DOI: 10.1007/s12026-014-8535-y
PMCID: PMC4686340
PMID: 24838145
Abstract
Leishmania amazonensis is an intracellular protozoan parasite responsible for chronic cutaneous leishmaniasis (CL). CL is a neglected tropical disease responsible for infecting millions of people worldwide. L. amazonensis promotes alteration of various signaling pathways that are essential for host cell survival. Specifically, through parasite-mediated phosphorylation of extracellular signal regulated kinase (ERK), L. amazonensis inhibits cell-mediated parasite killing and promotes its own survival by co-opting multiple host cell functions. In this review, we highlight Leishmania-host cell signaling alterations focusing on those specific to (1) motor proteins, (2) prevention of NADPH subunit phosphorylation impairing reactive oxygen species production, and (3) localized endosomal signaling to up-regulate ERK phosphorylation. This review will focus upon mechanisms and possible explanations as to how Leishmania spp. evades the various layers of defense employed by the host immune response.
Details
- Title: Subtitle
- Chronic infection by Leishmania amazonensis mediated through MAPK ERK mechanisms
- Creators
- Pedro A Martinez - Department of Epidemiology, College of Public Health, University of Iowa, S429 CPHB, 145 Riverside Drive, Iowa City, IA, 52242, USAChristine A Petersen
- Resource Type
- Journal article
- Publication Details
- Immunologic research, Vol.59(1-3), pp.153-165
- DOI
- 10.1007/s12026-014-8535-y
- PMID
- 24838145
- PMCID
- PMC4686340
- NLM abbreviation
- Immunol Res
- ISSN
- 0257-277X
- eISSN
- 1559-0755
- Publisher
- United States
- Grant note
- R21 AI074711 / NIAID NIH HHS L60 MD000401 / NIMHD NIH HHS
- Language
- English
- Date published
- 08/2014
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9983995044502771
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