Chronic intestinal pseudoobstruction associated with fetal alcohol syndrome

A Uc; E Vasiliauskas; D A Piccoli; A F Flores; C Di Lorenzo; P E Hyman

doi:10.1023/A:1018833503080

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Chronic intestinal pseudoobstruction associated with fetal alcohol syndrome

Journal article

Peer reviewed

Chronic intestinal pseudoobstruction associated with fetal alcohol syndrome

A Uc, E Vasiliauskas, D A Piccoli, A F Flores, C Di Lorenzo and P E Hyman

Digestive diseases and sciences, Vol.42(6), pp.1163-1167

06/1997

DOI: 10.1023/A:1018833503080

PMID: 9201078

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Abstract

Alcohol acts as a teratogen in the fetus, resulting in prenatal or postnatal growth failure, characteristic facial dysmorphic features, and central nervous system dysfunction. The toxic effects of alcohol on the developing brain are well recognized, but gastrointestinal neuropathy has not been described in fetal alcohol syndrome (FAS). Five children with FAS presented in infancy with signs and symptoms suggestive of chronic intestinal pseudoobstruction. They were not able to sustain adequate caloric intake by mouth, and all required prolonged special methods of alimentation. We performed antroduodenal manometry in these children to determine whether their symptoms were associated with a gastrointestinal motility disorder. All patients had abnormally propagating phase III-like episodes during fasting (retrograde in four, simultaneous in two). Persistent clusters of stationary contractions were a prominent feature in two patients. In utero neurotoxicity of alcohol may not be limited to the central nervous system, but may also cause an enteric neuropathy presenting in infancy as chronic intestinal pseudoobstruction.

Manometry

Humans

Child, Preschool

Infant

Male

Pyloric Antrum - physiopathology

Intestinal Pseudo-Obstruction - physiopathology

Intestinal Pseudo-Obstruction - diagnosis

Duodenum - physiopathology

Female

Myoelectric Complex, Migrating - physiology

Fetal Alcohol Spectrum Disorders - complications

Intestinal Pseudo-Obstruction - etiology

Child

Details

Title: Subtitle: Chronic intestinal pseudoobstruction associated with fetal alcohol syndrome
Creators: A Uc - Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
E Vasiliauskas
D A Piccoli
A F Flores
C Di Lorenzo
P E Hyman
Resource Type: Journal article
Publication Details: Digestive diseases and sciences, Vol.42(6), pp.1163-1167
Publisher: United States
DOI: 10.1023/A:1018833503080
PMID: 9201078
ISSN: 0163-2116
eISSN: 1573-2568
Language: English
Date published: 06/1997
Academic Unit: Stead Family Department of Pediatrics; Radiation Oncology; Gastroenterology, Hepatology, Pancreatology, and Nutrition
Record Identifier: 9984047780502771

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