Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials

Laura C Amann; Tobias B Halene; Richard S Ehrlichman; Stephen N Luminais; Nan Ma; Ted Abel; Steven J Siegel

doi:10.1016/j.nbd.2009.05.012

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Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials

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Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials

Laura C Amann, Tobias B Halene, Richard S Ehrlichman, Stephen N Luminais, Nan Ma, Ted Abel and Steven J Siegel

Neurobiology of disease, Vol.35(2), pp.311-317

08/2009

DOI: 10.1016/j.nbd.2009.05.012

PMCID: PMC2726963

PMID: 19467327

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https://doaj.org/article/28f74695b36f4fbca6b3e5bac47ddf2aView

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Abstract

Ketamine is an NMDA receptor antagonist with a variety of uses, ranging from recreational drug to pediatric anesthetic and chronic pain reliever. Despite its value in the clinical setting, little is known about the immediate and long-lasting effects of repeated ketamine treatment. We assessed the effects of chronic administration of a subanesthetic dose of ketamine on contextual fear conditioning, detection of pitch deviants and auditory gating. After four, but not two, weeks of daily ketamine injections, mice exhibited decreased freezing in the fear conditioning paradigm. Gating of the P80 component of auditory evoked potentials was also significantly altered by treatment condition, as ketamine caused a significant decrease in S1 amplitude. Additionally, P20 latency was significantly increased as a result of ketamine treatment. Though no interactions were found involving test week, stimulus and treatment condition, these results suggest that repeated ketamine administration impairs fear memory and has lasting effects on encoding of sensory stimuli.

Drug abuse

Auditory evoked potential (AEP)

Ketamine

Event-related potential (ERP)

Schizophrenia

Gating

Fear conditioning

Details

Title: Subtitle: Chronic ketamine impairs fear conditioning and produces long-lasting reductions in auditory evoked potentials
Creators: Laura C Amann - SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Tobias B Halene - SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Richard S Ehrlichman - SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Stephen N Luminais - SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Nan Ma - Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
Ted Abel - Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
Steven J Siegel - SMRI Laboratory for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Resource Type: Journal article
Publication Details: Neurobiology of disease, Vol.35(2), pp.311-317
DOI: 10.1016/j.nbd.2009.05.012
PMID: 19467327
PMCID: PMC2726963
NLM abbreviation: Neurobiol Dis
ISSN: 0969-9961
eISSN: 1095-953X
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000026, name: National Institute on Drug Abuse, award: 1 R01 DA023210-01; DOI: 10.13039/100000054, name: National Cancer Institute, award: P50-CA-084718; DOI: 10.13039/501100001659, name: Deutsche Forschungsgemeinschaft, award: IRTG 1328; DOI: 10.13039/100000025, name: National Institute of Mental Health, award: P50 MH064045
Language: English
Date published: 08/2009
Academic Unit: Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
Record Identifier: 9984065835702771

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