Journal article
Chronic kidney disease in the neonate: etiologies, management, and outcomes
Seminars in fetal & neonatal medicine, Vol.22(2), pp.98-103
04/01/2017
DOI: 10.1016/j.siny.2016.09.003
PMID: 27733241
Abstract
Neonatal chronic kidney disease (CKD) occurs with an estimated incidence of 1 in 10,000 live births, whereas the incidence of neonatal end-stage renal disease (ESRD) is about 7.1 per million age-related population. The most frequent etiologies are renal hypoplasia/dysplasia, posterior urethral valves, and other congenital anomalies of the kidney and urinary tract. Other etiologies include polycystic kidney disease, cortical necrosis, and renal vascular thrombosis. Management of CKD focuses primarily on replacing renal functions such as erythropoietin, 1,25-hydroxylation of vitamin D, electrolyte homeostasis/excretion, and, in ESRD, waste product removal. Nutrition and growth monitoring are of utmost importance, with the majority of ESRD infants requiring gastrostomy tube for nutrition. Outcomes of neonates (<31 days) started on dialysis continue to improve, with large cohort studies showing 2-3-year survival rates of 79-81%. As in other neonatal disciplines, the gestational age and size limits for safe provision of dialysis continue to decrease. (C) 2016 Elsevier Ltd. All rights reserved.
Details
- Title: Subtitle
- Chronic kidney disease in the neonate: etiologies, management, and outcomes
- Creators
- Jason Misurac - University of Iowa Stead Family Children’s Hospital
- Resource Type
- Journal article
- Publication Details
- Seminars in fetal & neonatal medicine, Vol.22(2), pp.98-103
- Publisher
- Elsevier
- DOI
- 10.1016/j.siny.2016.09.003
- PMID
- 27733241
- ISSN
- 1744-165X
- eISSN
- 1878-0946
- Number of pages
- 6
- Language
- English
- Date published
- 04/01/2017
- Academic Unit
- Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics
- Record Identifier
- 9984353849502771
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