Chronic lymphocytic leukaemia : an overview of aetiology in light of recent developments in classification and pathogenesis

Martha S Linet; Mary K SCHUBAUER-BERIGAN; Graca M Dores; Dennis D Weisenburger; David B Richardson; Ola Landgren; Aaron Blair; Sharon Silver; R. William Field; Glyn Caldwell; Maureen Hatch

doi:10.1111/j.1365-2141.2007.06847.x

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Chronic lymphocytic leukaemia : an overview of aetiology in light of recent developments in classification and pathogenesis

Journal article

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Peer reviewed

Chronic lymphocytic leukaemia : an overview of aetiology in light of recent developments in classification and pathogenesis

Martha S Linet, Mary K SCHUBAUER-BERIGAN, Graca M Dores, Dennis D Weisenburger, David B Richardson, Ola Landgren, Aaron Blair, Sharon Silver, R. William Field, Glyn Caldwell, …

British journal of haematology, Vol.139(5), pp.672-686

2007

DOI: 10.1111/j.1365-2141.2007.06847.x

PMID: 18021081

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Abstract

This overview of the epidemiology of chronic lymphocytic leukaemia (CLL) summarizes the evolution of classification and coding systems and describes the intersection of pathogenesis and aetiology. The role of the putative precursor to CLL, monoclonal B-cell lymphocytosis (MBL), is considered, and ideas for future investigations of the MBL-CLL relationship are outlined. We discuss the epidemiology of CLL, focusing on descriptive patterns and methodological considerations. Postulated risk factors are reviewed including the role of ionizing and non-ionizing radiation, occupational and environmental chemical exposures, medical conditions and treatments, and lifestyle and genetic factors. We conclude by raising key questions that need to be addressed to advance our understanding of CLL aetiology. Recommendations for future epidemiological studies are given, including the standardization of reporting of CLL across cancer registries, the clarification of the natural history of MBL, and the circumvention of the methodological shortcomings of prior epidemiological investigations in relation to radiation, chemical exposures and infectious agents.

Biological and medical sciences

Hematologic and hematopoietic diseases

Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis

Medical sciences

Details

Title: Subtitle: Chronic lymphocytic leukaemia : an overview of aetiology in light of recent developments in classification and pathogenesis
Creators: Martha S Linet - National Cancer Institute
Mary K SCHUBAUER-BERIGAN - National Institute for Occupational Safety and Health
Graca M Dores - National Cancer Institute
Dennis D Weisenburger - University of Nebraska Medical Center
David B Richardson - School of Public Health, University of North Carolina, Chapel Hill, NC, United States
Ola Landgren - DCEG/Genetic Epidemiology Branch, National Cancer Institute, Bethesda, MD
Aaron Blair - DCEG/Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD
Sharon Silver - National Institute for Occupational Safety and Health
R. William Field - University of Iowa
Glyn Caldwell - University of Iowa
Maureen Hatch - National Cancer Institute
Resource Type: Journal article
Publication Details: British journal of haematology, Vol.139(5), pp.672-686
DOI: 10.1111/j.1365-2141.2007.06847.x
PMID: 18021081
NLM abbreviation: Br J Haematol
ISSN: 0007-1048
eISSN: 1365-2141
Publisher: Blackwell
Language: English
Date published: 2007
Academic Unit: Occupational and Environmental Health; Epidemiology
Record Identifier: 9984364441202771

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