Journal article
Chronic non-inflammatory muscle pain: central and peripheral mediators
Current opinion in physiology, Vol.11, pp.67-74
10/2019
DOI: 10.1016/j.cophys.2019.06.006
PMCID: PMC6988739
PMID: 31998857
Abstract
Conditions with chronic widespread non-inflammatory muscle pain, such as fibromyalgia, have complex etiologies with numerous proposed mechanisms for their pathophysiology of underlying chronic pain. Advancements in neuroimaging have allowed for the study of brain function and connectivity in humans with these conditions, while development of animal models have allowed for the study of both peripheral and central factors that lead to chronic pain. This article reviews the current literature surrounding the pathophysiology of chronic widespread non-inflammatory muscle pain focusing on both peripheral and central nervous system, as well as immune system, contributions to the development and maintenance of pain. A better understanding of the mechanisms underlying these conditions can allow for improvements in patient education, treatment and outcomes.
Details
- Title: Subtitle
- Chronic non-inflammatory muscle pain: central and peripheral mediators
- Creators
- Joseph Lesnak - Department of Physical Therapy and Rehabilitation Science, Pain Research Program, 1-242 MEB, University of Iowa, Iowa City, IA 52252, USAKathleen A Sluka - Department of Physical Therapy and Rehabilitation Science, Pain Research Program, 1-242 MEB, University of Iowa, Iowa City, IA 52252, USA
- Resource Type
- Journal article
- Publication Details
- Current opinion in physiology, Vol.11, pp.67-74
- Publisher
- England
- DOI
- 10.1016/j.cophys.2019.06.006
- PMID
- 31998857
- PMCID
- PMC6988739
- ISSN
- 2468-8673
- eISSN
- 2468-8673
- Grant note
- T32 GM067795 / NIGMS NIH HHS R01 AR073187 / NIAMS NIH HHS R01 AR061371 / NIAMS NIH HHS
- Language
- English
- Date published
- 10/2019
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984070547102771
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