Journal article
Chronic parvovirus B19 infection and systemic necrotising vasculitis: opportunistic infection or aetiological agent?
The Lancet (British edition), Vol.343(8908), pp.1255-1258
05/21/1994
DOI: 10.1016/S0140-6736(94)92152-0
PMID: 7910276
Abstract
We describe three patients who had infection with human parvovirus B19 in association with new-onset systemic necrotising vasculitis syndromes, two with features of polyarteritis nodosa and one with features of Wegener's granulomatosis. Chronic B19 infection, lasting 5 months to more than 3 years, was shown by enzyme immunoassay for IgG and IgM antibodies to B19 and polymerase chain reaction for B19 DNA in serum and tissue samples. The patients had atypical serological responses to the B19 infection, although none had a recognisable immunodeficiency disorder. Treatment with corticosteroids and cyclophosphamide did not control vasculitis. Intravenous immunoglobulin (IVIG) therapy led to rapid improvement of the systemic vascultis manifestations, clearing of the chronic parvovirus infection, and long-term remission. These observations suggest an aetiological relation between parvovirus B19 infection and systemic necrotisingvasculitis in these patients and indicate a potentially curative role for IVIG in such disorders.
Details
- Title: Subtitle
- Chronic parvovirus B19 infection and systemic necrotising vasculitis: opportunistic infection or aetiological agent?
- Creators
- Terri H Finkel - Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206, U.S.AT.J Török - Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United StatesPolly J Ferguson - Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville, Virginia, United StatesE.L Durigon - Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, BrazilS.R Zaki - Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United StatesDonald Y M Leung - Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206, U.S.ARonald J Harbeck - Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206, U.S.AE.W Gelfand - Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206, U.S.AFrank T Saulsbury - Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville, Virginia, United StatesJ.R Hollister - Children's Hospital, University of Colorado Health Sciences Center, Denver, U.S.ALarry J Anderson - Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States
- Resource Type
- Journal article
- Publication Details
- The Lancet (British edition), Vol.343(8908), pp.1255-1258
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0140-6736(94)92152-0
- PMID
- 7910276
- ISSN
- 0140-6736
- eISSN
- 1474-547X
- Language
- English
- Date published
- 05/21/1994
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Rheumatology, Allergy, and Immunology
- Record Identifier
- 9984065822002771
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