Journal article
Chronic social defeat stress disrupts regulation of lipid synthesis[S]
Journal of lipid research, Vol.51(6), pp.1344-1353
06/2010
DOI: 10.1194/jlr.M002196
PMCID: PMC3035497
PMID: 20129912
Abstract
Several psychiatric disorders increase the risk of cardiovascular disease, including posttraumatic stress disorder and major depression. While the precise mechanism for this association has not yet been established, it has been shown that certain disorders promote an unfavorable lipid profile. To study the interaction of stress and lipid dysregulation, we utilized chronic social defeat stress (CSDS), a mouse model of chronic stress with features of posttraumatic stress disorder and major depression. Following exposure to CSDS, mice were given access to either regular chow or a Western-style diet high in fat and cholesterol (HFD). The combination of social stress and HFD resulted in significant perturbations in lipid regulation, including two key features of the metabolic syndrome: increased plasma levels of non–HDL cholesterol and intrahepatic accumulation of triglycerides. These effects were accompanied by a number of changes in the expression of hepatic genes involved in lipid regulation. Transcriptional activity of LXR, SREBP1c, and ChREBP were significantly affected by exposure to HFD and CSDS. We present CSDS as a model of social stress induced lipid dysregulation and propose that social stress alters lipid metabolism by increasing transcriptional activity of genes involved in lipid synthesis.
Details
- Title: Subtitle
- Chronic social defeat stress disrupts regulation of lipid synthesis[S]
- Creators
- Jen-Chieh Chuang - Internal Medicine (Division of Hypothalamic Research), University of Texas Southwestern Medical Center, Dallas, TX, 75390Huxing Cui - Departments of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, 75390Brittany L Mason - Departments of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, 75390Melissa Mahgoub - Departments of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, 75390Angie L Bookout - Internal Medicine (Division of Hypothalamic Research), University of Texas Southwestern Medical Center, Dallas, TX, 75390Hana G Yu - Departments of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, 75390Mario Perello - Internal Medicine (Division of Hypothalamic Research), University of Texas Southwestern Medical Center, Dallas, TX, 75390Joel K Elmquist - Departments of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, 75390Joyce J Repa - Internal Medicine (Division of Hypothalamic Research), University of Texas Southwestern Medical Center, Dallas, TX, 75390Jeffrey M Zigman - Departments of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, 75390Michael Lutter - Departments of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, 75390
- Resource Type
- Journal article
- Publication Details
- Journal of lipid research, Vol.51(6), pp.1344-1353
- DOI
- 10.1194/jlr.M002196
- PMID
- 20129912
- PMCID
- PMC3035497
- NLM abbreviation
- J Lipid Res
- ISSN
- 0022-2275
- eISSN
- 1539-7262
- Publisher
- The American Society for Biochemistry and Molecular Biology
- Language
- English
- Date published
- 06/2010
- Academic Unit
- Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology
- Record Identifier
- 9984040479102771
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