Journal article
Chronic stress and brain plasticity: Mechanisms underlying adaptive and maladaptive changes and implications for stress-related CNS disorders
Neuroscience and biobehavioral reviews, Vol.58, pp.79-91
11/2015
DOI: 10.1016/j.neubiorev.2015.06.018
PMCID: PMC4684432
PMID: 26116544
Abstract
Stress responses entail neuroendocrine, autonomic, and behavioral changes to promote effective coping with real or perceived threats to one's safety. While these responses are critical for the survival of the individual, adverse effects of repeated exposure to stress are widely known to have deleterious effects on health. Thus, a considerable effort in the search for treatments to stress-related CNS disorders necessitates unraveling the brain mechanisms responsible for adaptation under acute conditions and their perturbations following chronic stress exposure. This paper is based upon a symposium from the 2014 International Behavioral Neuroscience Meeting, summarizing some recent advances in understanding the effects of stress on adaptive and maladaptive responses subserved by limbic forebrain networks. An important theme highlighted in this review is that the same networks mediating neuroendocrine, autonomic, and behavioral processes during adaptive coping also comprise targets of the effects of repeated stress exposure in the development of maladaptive states. Where possible, reference is made to the similarity of neurobiological substrates and effects observed following repeated exposure to stress in laboratory animals and the clinical features of stress-related disorders in humans.
Details
- Title: Subtitle
- Chronic stress and brain plasticity: Mechanisms underlying adaptive and maladaptive changes and implications for stress-related CNS disorders
- Creators
- Jason Radley - Department of Psychological and Brain Sciences and Interdisciplinary Neuroscience Program, University of Iowa, IA, United StatesDavid Morilak - Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX, United StatesVictor Viau - Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, CanadaSerge Campeau - Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO, United States. Electronic address: serge.campeau@colorado.edu
- Resource Type
- Journal article
- Publication Details
- Neuroscience and biobehavioral reviews, Vol.58, pp.79-91
- DOI
- 10.1016/j.neubiorev.2015.06.018
- PMID
- 26116544
- PMCID
- PMC4684432
- NLM abbreviation
- Neurosci Biobehav Rev
- ISSN
- 0149-7634
- eISSN
- 1873-7528
- Publisher
- United States
- Grant note
- R29 MH053851 / NIMH NIH HHS R01 MH095972 / NIMH NIH HHS R01 MH077152 / NIMH NIH HHS MOP-136856 / Canadian Institutes of Health Research MH072672 / NIMH NIH HHS R01 MH053851 / NIMH NIH HHS R01 MH072672 / NIMH NIH HHS MH077152 / NIMH NIH HHS MOP-136840 / Canadian Institutes of Health Research MH053851 / NIMH NIH HHS MH095972 / NIMH NIH HHS
- Language
- English
- Date published
- 11/2015
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984070492602771
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