Chronologic changes of explanted liver volume and the use of ursodeoxycholic acid in patients with end‐stage primary biliary cirrhosis

Tomohiro Tanaka; Noriyo Yamashiki; Yasuhiko Sugawara; Sumihito Tamura; Minoru Nakamura; Junichi Kaneko; Taku Aoki; Yoshihiro Sakamoto; Kiyoshi Hasegawa; Norihiro Kokudo

doi:10.1111/hepr.12283

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Chronologic changes of explanted liver volume and the use of ursodeoxycholic acid in patients with end‐stage primary biliary cirrhosis

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Chronologic changes of explanted liver volume and the use of ursodeoxycholic acid in patients with end‐stage primary biliary cirrhosis

Tomohiro Tanaka, Noriyo Yamashiki, Yasuhiko Sugawara, Sumihito Tamura, Minoru Nakamura, Junichi Kaneko, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa and Norihiro Kokudo

Hepatology research, Vol.44(9), pp.993-999

09/2014

DOI: 10.1111/hepr.12283

PMID: 24298893

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Abstract

Aim The clinical presentation of Primary biliary cirrhosis (PBC) at the time of liver transplantation (LT) may have changed, due to the long‐term use of ursodeoxycholic acid (UDCA). The aim of this retrospective study was to investigate whether the clinical characteristics of LT recipients with PBC have changed over the years. Methods Of all 421 adults undergoing LT from 1997 to 2012 at our center, we included 85 recipients with PBC into the present study. The 85 recipients were divided into three groups according to the year LT was performed: group 1 (1997–2001, n = 29), group 2 (2002–2005, n = 29) and group 3 (2006–2012, n = 27). Results There were no significant differences in sex, recipient age, Model for End‐Stage Liver Disease score, updated Mayo risk score for PBC, or liver‐related complications except for esophageal varices among the three groups. Patients in group 1 were complicated with esophageal varices less frequently than those in the other two groups. In older cases, the ratio of explanted liver volume to standard liver volume (ELV/SLV) was significantly higher, and the duration of pre‐LT UDCA treatment was significantly shorter. The duration of UDCA treatment was significantly correlated with ELV/SLV. Conclusion Recent LT patients were characterized by more frequent portal hypertension and more severe liver atrophy, with longer UDCA therapy prior to LT, which might have prevented the somewhat rapid progression of liver failure characterized by hepatomegaly with insignificant fibrosis or portal hypertension.

hepatomegaly

explanted liver

primary biliary cirrhosis

liver transplantation

living donor liver transplantation

Details

Title: Subtitle: Chronologic changes of explanted liver volume and the use of ursodeoxycholic acid in patients with end‐stage primary biliary cirrhosis
Creators: Tomohiro Tanaka - The University of Tokyo Hospital
Noriyo Yamashiki - The University of Tokyo Hospital
Yasuhiko Sugawara - The University of Tokyo
Sumihito Tamura - The University of Tokyo
Minoru Nakamura - National Hospital Organization Nagasaki Medical Center
Junichi Kaneko - The University of Tokyo
Taku Aoki - The University of Tokyo
Yoshihiro Sakamoto - The University of Tokyo
Kiyoshi Hasegawa - The University of Tokyo
Norihiro Kokudo - The University of Tokyo
Resource Type: Journal article
Publication Details: Hepatology research, Vol.44(9), pp.993-999
DOI: 10.1111/hepr.12283
PMID: 24298893
ISSN: 1386-6346
eISSN: 1872-034X
Number of pages: 7
Grant note: Ministry of Health, Labor and Welfare of Japan Ministry of Education, Culture, Sports, Science and Technology of Japan
Language: English
Date published: 09/2014
Academic Unit: Gastroenterology and Hepatology; Internal Medicine
Record Identifier: 9984094577202771

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