Journal article
Chronometric Electrical Stimulation of Right Inferior Frontal Cortex Increases Motor Braking
The Journal of neuroscience, Vol.33(50), pp.19611-19619
12/11/2013
DOI: 10.1523/JNEUROSCI.3468-13.2013
PMCID: PMC3858630
PMID: 24336725
Abstract
The right inferior frontal cortex (rIFC) is important for stopping responses. Recent research shows that it is also activated when response emission is slowed down when stopping is anticipated. This suggests that rIFC also functions as a goal-driven brake. Here, we investigated the causal role of rIFC in goal-driven braking by using computer-controlled, event-related (chronometric), direct electrical stimulation (DES). We compared the effects of rIFC stimulation on trials in which responses were made in the presence versus absence of a stopping-goal (“Maybe Stop” [MS] vs “No Stop” [NS]). We show that DES of rIFC slowed down responses (compared with control-site stimulation) and that rIFC stimulation induced more slowing when motor braking was required (MS) compared with when it was not (NS). Our results strongly support a causal role of a rIFC-based network in inhibitory motor control. Importantly, the results extend this causal role beyond externally driven stopping to goal-driven inhibitory control, which is a richer model of human self-control. These results also provide the first demonstration of double-blind chronometric DES of human prefrontal cortex, and suggest that—in the case of rIFC—this could lead to augmentation of motor braking.
Details
- Title: Subtitle
- Chronometric Electrical Stimulation of Right Inferior Frontal Cortex Increases Motor Braking
- Creators
- Jan R Wessel - Psychology Department, University of California, San Diego, La Jolla, California 92093, andChristopher R Conner - Department of Neurosurgery, University of Texas Medical School at Houston, andAdam R Aron - Psychology Department, University of California, San Diego, La Jolla, California 92093, andNitin Tandon - Memorial Hermann Hospital, Texas Medical Center, Houston, Texas 77030
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.33(50), pp.19611-19619
- DOI
- 10.1523/JNEUROSCI.3468-13.2013
- PMID
- 24336725
- PMCID
- PMC3858630
- NLM abbreviation
- J Neurosci
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Publisher
- Society for Neuroscience
- Language
- English
- Date published
- 12/11/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002477902771
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