Journal article
Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder
Neuropsychopharmacology (New York, N.Y.), Vol.44(3), pp.620-628
02/2019
DOI: 10.1038/s41386-018-0273-8
PMCID: PMC6333516
PMID: 30487653
Abstract
Bipolar disorder (BD) is a serious mood disorder associated with circadian rhythm abnormalities. Risk for BD is genetically encoded and overlaps with systems that maintain circadian rhythms. Lithium is an effective mood stabilizer treatment for BD, but only a minority of patients fully respond to monotherapy. Presently, we hypothesized that lithium-responsive BD patients (Li-R) would show characteristic differences in chronotype and cellular circadian rhythms compared to lithium non-responders (Li-NR). Selecting patients from a prospective, multi-center, clinical trial of lithium monotherapy, we examined morning vs. evening preference (chronotype) as a dimension of circadian rhythm function in 193 Li-R and Li-NR BD patients. From a subset of 59 patient donors, we measured circadian rhythms in skin fibroblasts longitudinally over 5 days using a bioluminescent reporter (Per2-luc). We then estimated circadian rhythm parameters (amplitude, period, phase) and the pharmacological effects of lithium on rhythms in cells from Li-R and Li-NR donors. Compared to Li-NRs, Li-Rs showed a difference in chronotype, with higher levels of morningness. Evening chronotype was associated with increased mood symptoms at baseline, including depression, mania, and insomnia. Cells from Li-Rs were more likely to exhibit a short circadian period, a linear relationship between period and phase, and period shortening effects of lithium. Common genetic variation in the IP
Details
- Title: Subtitle
- Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder
- Creators
- Michael J McCarthy - Psychiatry Service, VA San Diego Healthcare, San Diego, CA, 92161, USA. mmccarthy@ucsd.eduHeather Wei - Psychiatry Service, VA San Diego Healthcare, San Diego, CA, 92161, USACaroline M Nievergelt - Department of Psychiatry and Center for Circadian Biology, University of California, San Diego, 3350 La Jolla Village Dr. MC 116A, San Diego, CA, 92161, USAAndrea Stautland - Department of Clinical Medicine, Section for Psychiatry, University of Bergen, Bergen, NorwayAdam X Maihofer - Department of Psychiatry and Center for Circadian Biology, University of California, San Diego, 3350 La Jolla Village Dr. MC 116A, San Diego, CA, 92161, USADavid K Welsh - Psychiatry Service, VA San Diego Healthcare, San Diego, CA, 92161, USAPaul Shilling - Department of Psychiatry and Center for Circadian Biology, University of California, San Diego, 3350 La Jolla Village Dr. MC 116A, San Diego, CA, 92161, USAMartin Alda - Department of Psychiatry, Dalhousie University, Halifax, CanadaNey Alliey-Rodriguez - Department of Psychiatry, University of Chicago, Chicago, USAAmit Anand - Department of Psychiatry, Indiana University, Bloomington, USAOle A Andreasson - Jebsen Centre for Psychosis Research, University of Oslo, Oslo, NorwayYokesh Balaraman - Department of Psychiatry, Indiana University, Bloomington, USAWade H Berrettini - Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USAHolli Bertram - Department of Psychiatry, University of Michigan, Ann Arbor, MI, USAKristen J Brennand - Departments of Neuroscience and Psychiatry, Icahn School of Medicine at Mt Sinai, New York, USAJoseph R Calabrese - Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USACynthia V Calkin - Department of Psychiatry, Dalhousie University, Halifax, CanadaAna Claasen - Neurogenomics Division, Translational Genomics Research Institute, Phoenix, USAClara Conroy - Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USAWilliam H Coryell - Department of Psychiatry, University of Iowa, Iowa City, USADavid W Craig - Neurogenomics Division, Translational Genomics Research Institute, Phoenix, USANicole D'Arcangelo - Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USAAnna Demodena - Psychiatry Service, VA San Diego Healthcare, San Diego, CA, 92161, USASrdjan Djurovic - Jebsen Centre for Psychosis Research, University of Oslo, Oslo, NorwayScott Feeder - Department of Psychiatry, The Mayo Clinic, Rochester, USACarrie Fisher - Department of Psychiatry, Indiana University, Bloomington, USANicole Frazier - Department of Psychiatry, University of Michigan, Ann Arbor, MI, USAMark A Frye - Department of Psychiatry, The Mayo Clinic, Rochester, USAFred H Gage - Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, USAKeming Gao - Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USAJulie Garnham - Department of Psychiatry, Dalhousie University, Halifax, CanadaElliot S Gershon - Department of Psychiatry, University of Chicago, Chicago, USAKara Glazer - Department of Psychiatry, Johns Hopkins University, Baltimore, USAFernando Goes - Department of Psychiatry, Johns Hopkins University, Baltimore, USAToyomi Goto - Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USAGloria Harrington - Department of Psychiatry, University of Michigan, Ann Arbor, MI, USAPetter Jakobsen - Norment and KG Jebsen Centre for Neuropsychiatry, Division of Psychiatry, Haukeland University Hospital, Bergen, NorwayMasoud Kamali - Department of Psychiatry, University of Michigan, Ann Arbor, MI, USAElizabeth Karberg - Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USAMarisa Kelly - Department of Psychiatry, University of Michigan, Ann Arbor, MI, USASusan G Leckband - Psychiatry Service, VA San Diego Healthcare, San Diego, CA, 92161, USAFalk Lohoff - Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USAMelvin G McInnis - Department of Psychiatry, University of Michigan, Ann Arbor, MI, USAFrancis Mondimore - Department of Psychiatry, Johns Hopkins University, Baltimore, USAGunnar Morken - Division of Psychiatry, St. Olav University Hospital of Trondheim and Department of Mental Health Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, NorwayJohn I Nurnberger - Department of Psychiatry, Indiana University, Bloomington, USASarah Obral - Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USAKetil J Oedegaard - Norment and KG Jebsen Centre for Neuropsychiatry, Division of Psychiatry, Haukeland University Hospital, Bergen, NorwayAbigail Ortiz - Department of Psychiatry, University of Ottawa, Ottawa, ON, CanadaMegan Ritchey - Department of Psychiatry, Johns Hopkins University, Baltimore, USAKelly Ryan - Department of Psychiatry, University of Michigan, Ann Arbor, MI, USAMartha Schinagle - Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USAHelle Schoeyen - Department of Clinical Medicine, Section for Psychiatry, University of Bergen, Bergen, NorwayCandice Schwebel - Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USAMartha Shaw - Department of Psychiatry, University of Chicago, Chicago, USATatyana Shekhtman - Psychiatry Service, VA San Diego Healthcare, San Diego, CA, 92161, USAClaire Slaney - Department of Psychiatry, Dalhousie University, Halifax, CanadaEmma Stapp - Department of Psychiatry, Johns Hopkins University, Baltimore, USASzabolcs Szelinger - Neurogenomics Division, Translational Genomics Research Institute, Phoenix, USABruce Tarwater - Neurogenomics Division, Translational Genomics Research Institute, Phoenix, USAPeter P Zandi - Department of Psychiatry, Johns Hopkins University, Baltimore, USAJohn R Kelsoe - Psychiatry Service, VA San Diego Healthcare, San Diego, CA, 92161, USA
- Resource Type
- Journal article
- Publication Details
- Neuropsychopharmacology (New York, N.Y.), Vol.44(3), pp.620-628
- Publisher
- England
- DOI
- 10.1038/s41386-018-0273-8
- PMID
- 30487653
- PMCID
- PMC6333516
- ISSN
- 1740-634X
- eISSN
- 1740-634X
- Grant note
- MH92758 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) I01 BX001146 / BLRD VA U01MH092758 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) I01 BX003431 / BLRD VA U01 MH092758 / NIMH NIH HHS
- Language
- English
- Date published
- 02/2019
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003462702771
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