Journal article
Cigarette Smoking and Cancer Risk: Modeling Total Exposure and Intensity
American journal of epidemiology, Vol.166(4), pp.479-489
06/04/2007
DOI: 10.1093/aje/kwm089
PMID: 17548786
Abstract
A recent analysis showed that the excess odds ratio (EOR) for lung cancer due to smoking can be modeled by a function which is linear in total pack-years and exponential in the logarithm of smoking intensity and its square. Below 15–20 cigarettes per day, the EOR/pack-year increased with intensity (direct exposure rate or enhanced potency effect), suggesting greater risk for a total exposure delivered at higher intensity (for a shorter duration) than for an equivalent exposure delivered at lower intensity. Above 20 cigarettes per day, the EOR/pack-year decreased with increasing intensity (inverse exposure rate or reduced potency effect), suggesting greater risk for a total exposure delivered at lower intensity (for a longer duration) than for an equivalent exposure delivered at higher intensity. The authors applied this model to data from 10 case-control studies of cancer, including cancers of the lung, bladder, oral cavity, pancreas, and esophagus. At lower intensities, there was enhanced potency for several cancer sites, but narrow ranges for pack-years increased uncertainty, precluding definitive conclusions. At higher intensities, there was a consistent reduced potency effect across studies. The intensity effects were statistically homogeneous, indicating that after accounting for risk from total pack-years, intensity patterns were comparable across the diverse cancer sites.
Details
- Title: Subtitle
- Cigarette Smoking and Cancer Risk: Modeling Total Exposure and Intensity
- Creators
- Jay H Lubin - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MDMichael C. R Alavanja - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MDNeil Caporaso - Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MDLinda M Brown - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MDRoss C Brownson - Department of Community Health, School of Public Health, St. Louis University, St. Louis, MOR. William Field - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IAMontserrat Garcia-Closas - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MDPatricia Hartge - Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MDMichael Hauptmann - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MDRichard B Hayes - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MDRuth Kleinerman - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MDManolis Kogevinas - Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research (IMIM), Barcelona, SpainDaniel Krewski - McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, CanadaBryan Langholz - Department of Preventive Medicine, School of Medicine, University of Southern California, Los Angeles, CAErnest G Létourneau - Radiation Protection Bureau, Health Protection Branch, Health Canada, Ottawa, Ontario, CanadaCharles F Lynch - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IANúria Malats - Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research (IMIM), Barcelona, SpainDale P Sandler - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NCAngelika Schaffrath-Rosario - Robert Koch-Institut, Abteilung Epidemiologie und Gesundheitsberichterstattung, Berlin, GermanyJanet B Schoenberg - Cancer Epidemiology Services, New Jersey Department of Health and Senior Services, Trenton, NJDebra T Silverman - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MDZuoyuan Wang - Laboratory of Industrial Hygiene, Ministry of Health, Beijing, ChinaH.-Erich Wichmann - Institute of Epidemiology, National Research Center for Environment and Health (GSF), Neuherberg, GermanyHomer B Wilcox - Cancer Epidemiology Services, New Jersey Department of Health and Senior Services, Trenton, NJJan M Zielinski - Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada
- Resource Type
- Journal article
- Publication Details
- American journal of epidemiology, Vol.166(4), pp.479-489
- Publisher
- Oxford University Press
- DOI
- 10.1093/aje/kwm089
- PMID
- 17548786
- ISSN
- 0002-9262
- eISSN
- 1476-6256
- Language
- English
- Date published
- 06/04/2007
- Academic Unit
- Occupational and Environmental Health; Epidemiology
- Record Identifier
- 9984216742002771
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