Cigarette smoking and airway wall thickness on CT scan in a multi-ethnic cohort: The MESA Lung Study

Kathleen M DONOHUE; Eric A HOFFMAN; Heather BAUMHAUER; Junfeng Guo; Matthew BUDOFF; John H. M AUSTIN; Ravi KALHAN; Steven KAWUT; Russell TRACY; R. Graham BARR

doi:10.1016/j.rmed.2012.08.006

Back

Cigarette smoking and airway wall thickness on CT scan in a multi-ethnic cohort: The MESA Lung Study

Journal article

Open access

Peer reviewed

Cigarette smoking and airway wall thickness on CT scan in a multi-ethnic cohort: The MESA Lung Study

Kathleen M DONOHUE, Eric A HOFFMAN, Heather BAUMHAUER, Junfeng Guo, Matthew BUDOFF, John H. M AUSTIN, Ravi KALHAN, Steven KAWUT, Russell TRACY and R. Graham BARR

Respiratory medicine, Vol.106(12), pp.1655-1664

2012

DOI: 10.1016/j.rmed.2012.08.006

PMCID: PMC3549633

PMID: 22974831

Files and links (1)

url

https://doi.org/10.1016/j.rmed.2012.08.006View

Published (Version of record) Open Access

Abstract

Background Autopsy studies show that smoking contributes to airway wall hyperplasia and narrowing of the airway lumen. Studies of smoking and airway measures on computed tomography (CT) scan are limited to case-control studies of measures that combine airway lumen and wall thickness. Objectives We hypothesized that cumulative cigarette smoking would be associated with increased airway wall thickness in a large, population-based cohort. Methods The Multi-Ethnic Study of Atherosclerosis enrolled participants age 45–84 years from the general population. Smoking history was assessed via standardized questionnaire items; current smoking was confirmed in half the cohort with cotinine. Airway lumen and wall thickness were measured in two dimensions in posterior basal segmental bronchi on cardiac-gated CT scans. Analyses were adjusted for age, gender, genetic ancestry, education, height, weight, asthma history, particulate matter, scanner type, and scanner current. Results Half of the 7898 participants had smoked and 14% were current smokers. Pack-years of smoking were associated with thicker airway walls (mean increase 0.002 mm per ten pack-years [95% CI: 0.00002, 0.004] p = 0.03). Current smoking was associated with narrower airway lumens (mean decrease −0.11 mm [95% CI: −0.2, −0.02] p = 0.02). There was no evidence that either association was modified by genetic ancestry, and findings persisted among participants without clinical disease. Conclusions Long-term cigarette smoking was associated with subclinical increases in wall thickness of sub-segmental airways whereas current smoking was associated with narrower airway lumen diameters. Smoking may contribute to airway wall thickening prior to the development of overt chronic obstructive pulmonary disease.

Toxicology

Biological and medical sciences

Medical sciences

Chronic obstructive pulmonary disease, asthma

Tobacco, tobacco smoking

Pneumology

Details

Title: Subtitle: Cigarette smoking and airway wall thickness on CT scan in a multi-ethnic cohort: The MESA Lung Study
Creators: Kathleen M DONOHUE - Columbia University, New York, NY 10032, United States
Eric A HOFFMAN - University of Iowa, Iowa City, IA 52242, United States
Heather BAUMHAUER - University of Iowa, Iowa City, IA 52242, United States
Junfeng Guo - University of Iowa, Iowa City, IA 52242, United States
Matthew BUDOFF - Los Angeles Biomedical Research Institute, Torrance, CA 90502, United States
John H. M AUSTIN - Columbia University, New York, NY 10032, United States
Ravi KALHAN - Northwestern University, Chicago, IL 60611, United States
Steven KAWUT - University of Pennsylvania, Philadelphia, PA 19104, United States
Russell TRACY - University of Vermont, Colchester, VT 5446, United States
R. Graham BARR - Columbia University, New York, NY 10032, United States
Resource Type: Journal article
Publication Details: Respiratory medicine, Vol.106(12), pp.1655-1664
Publisher: Elsevier; Kidlington
DOI: 10.1016/j.rmed.2012.08.006
PMID: 22974831
PMCID: PMC3549633
ISSN: 0954-6111
eISSN: 1532-3064
Language: English
Date published: 2012
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984051727702771

Metrics

16 Record Views

34 Times Cited - Web of Science