Journal article
Cigarette smoking and plasma high-density lipoprotein cholesterol. The Lipid Research Clinics Program Prevalence Study
Circulation (New York, N.Y.), Vol.62(4 Pt 2), pp.IV70-IV76
11/01/1980
PMID: 7418146
Abstract
The relationship between cigarette smoking and high-density lipoprotein (HDL) cholesterol was examined in 2663 men and 2553 women ages 20-69 years in 10 North American populations. Men and women who were smokers had significantly (p < 0.01) lower HDL cholesterol levels than nonsmokers, and heavier smokers had lower HDL cholesterol levels than lighter smokers. Using multiple linear regression analysis to adjust for differences in age, obesity, alcohol consumption and regular exercise increased the differences in HDL cholesterol levels between smokers and nonsmokers. For men who smoked 20 or more cigarettes/day, adjusted values averaged 5.3 mg/dl (11%) lower than those for nonsmokers (p < 0.01). Women who used gonadal hormones were analyzed separately from those who did not. In both groups, women who smoked 20 or more cigarettes/day had lower HDL cholesterol levels than nonsmokers: 9.4 mg/dl (14%) lower in hormone users and 8.6 mg/dl (14%) lower in nonusers (both p < 0.01). These findings indicate that cigarette smoking is associated with substantially lower levels of HDL cholesterol. Further, this association appears to be dose-dependent and is consistent with other research, indicating a possible causal relationship between cigarette smoking and lower HDL cholesterol.
Details
- Title: Subtitle
- Cigarette smoking and plasma high-density lipoprotein cholesterol. The Lipid Research Clinics Program Prevalence Study
- Creators
- M H CriquiR B WallaceG HeissM MishkelG SchonfeldG T Jones
- Resource Type
- Journal article
- Publication Details
- Circulation (New York, N.Y.), Vol.62(4 Pt 2), pp.IV70-IV76
- PMID
- 7418146
- NLM abbreviation
- Circulation
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Language
- English
- Date published
- 11/01/1980
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363641802771
Metrics
9 Record Views