Cimetidine-imipramine interaction: a case report

D D Miller; M Macklin

doi:10.1176/ajp.140.3.351

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Cimetidine-imipramine interaction: a case report

Journal article

Peer reviewed

Cimetidine-imipramine interaction: a case report

D D Miller and M Macklin

The American journal of psychiatry, Vol.140(3), pp.351-352

03/1983

DOI: 10.1176/ajp.140.3.351

PMID: 6829810

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Abstract

The authors describe the interaction of imipramine and cimetidine in a patient taking therapeutic doses of each. Cimetidine inhibited the metabolism of imipramine, leading to a prolonged half-life, elevated serum concentrations, and adverse effects.

Cimetidine - adverse effects

Humans

Half-Life

Depressive Disorder - drug therapy

Guanidines - pharmacology

Depressive Disorder - metabolism

Desipramine - metabolism

Drug Interactions

Imipramine - metabolism

Cimetidine - pharmacology

Adult

Female

Metabolic Clearance Rate - drug effects

Imipramine - pharmacology

Imipramine - adverse effects

Details

Title: Subtitle: Cimetidine-imipramine interaction: a case report
Creators: D D Miller
M Macklin
Resource Type: Journal article
Publication Details: The American journal of psychiatry, Vol.140(3), pp.351-352
Publisher: United States
DOI: 10.1176/ajp.140.3.351
PMID: 6829810
ISSN: 0002-953X
eISSN: 1535-7228
Language: English
Date published: 03/1983
Academic Unit: Psychiatry
Record Identifier: 9984003909902771

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