Cimetidine's effect on steady-state serum nortriptyline concentrations

D D Miller; J B Sawyer; J P Duffy

doi:10.1177/106002808301701209

Back

Journal article

Cimetidine's effect on steady-state serum nortriptyline concentrations

D D Miller, J B Sawyer and J P Duffy

Drug intelligence & clinical pharmacy, Vol.17(12), pp.904-905

12/1983

DOI: 10.1177/106002808301701209

PMID: 6653407

View Online

Abstract

A cimetidine-nortriptyline interaction in a 52-year-old black male is reported. After concomitant administration of cimetidine and nortriptyline for two weeks, steady-state nortriptyline concentrations fell 42 percent when cimetidine was discontinued. Later, during rechallenge with cimetidine, serum nortriptyline concentrations increased significantly, but subsequently fell again when cimetidine was discontinued. The possible clinical consequences of this interaction are discussed.

Peptic Ulcer - complications

Drug Interactions

Depressive Disorder - complications

Nortriptyline - blood

Humans

Middle Aged

Cimetidine - pharmacology

Depressive Disorder - drug therapy

Male

Peptic Ulcer - drug therapy

Details

Title: Subtitle: Cimetidine's effect on steady-state serum nortriptyline concentrations
Creators: D D Miller
J B Sawyer
J P Duffy
Resource Type: Journal article
Publication Details: Drug intelligence & clinical pharmacy, Vol.17(12), pp.904-905
Publisher: United States
DOI: 10.1177/106002808301701209
PMID: 6653407
ISSN: 0012-6578
Language: English
Date published: 12/1983
Academic Unit: Psychiatry
Record Identifier: 9984003424902771

Metrics

11 Record Views