Journal article
Circadian variation of tacrolimus disposition in liver allograft recipients
Transplantation, Vol.62(8), pp.1190-1192
1996
DOI: 10.1097/00007890-199610270-00031
PMID: 8900327
Abstract
The aim of this study was to characterize the circadian variation of oral tacrolimus disposition in 8 stable liver allograft recipients. In the steady state, a total of 23 blood samples was taken before and after tacrolimus administration during a 24-hr period and the pharmacokinetic parameters were compared. The area under the curve (AUC) of tacrolimus after the morning dose was significantly larger than after the evening dose(211±43 ng·hr/ml [morning] vs. 179±45 ng·hr/ml[evening], P=0.02). The time to peak (Tmax) was significantly shorter after the morning dose than after the evening dose(1.6±0.7 hr [morning] vs. 2.9±0.6 hr [evening],P=0.002). The peak (Cmax) was significantly higher after the morning dose than after the evening dose (32.2±10.2 ng/ml [morning] vs. 19.1±4.3 ng/ml [evening], P=0.003). However, the trough (Cmin) was not significantly different between the morning dose and the evening dose (13.1±3.9 ng/ml [morning] vs. 13.3±4.4 ng/ml[evening], P=0.4). This study demonstrated that tacrolimus disposition in liver transplant patients was determined by administration time.
Details
- Title: Subtitle
- Circadian variation of tacrolimus disposition in liver allograft recipients
- Creators
- David I Min - College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, United StatesHsiang-Yin Chen - College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, United StatesAlfredo Fabrega - Department of Surgery, University of Iowa, Iowa City, Iowa 52242, United StatesFerdinand O Ukah - University of IowaYou-Min Wu - Department of Surgery, University of Iowa, Iowa City, Iowa 52242, United StatesClaudia Corwin - Department of Surgery, University of Iowa, Iowa City, Iowa 52242, United StatesM. Kay Ashton - Department of Surgery, University of Iowa, Iowa City, Iowa 52242, United StatesMaureen Martin - Department of Surgery, University of Iowa, Iowa City, Iowa 52242, United States
- Resource Type
- Journal article
- Publication Details
- Transplantation, Vol.62(8), pp.1190-1192
- DOI
- 10.1097/00007890-199610270-00031
- PMID
- 8900327
- NLM abbreviation
- Transplantation
- ISSN
- 0041-1337
- eISSN
- 1534-6080
- Publisher
- Lippincott
- Language
- English
- Date published
- 1996
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Occupational and Environmental Health; Internal Medicine
- Record Identifier
- 9984094655102771
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